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| http://purl.uniprot.org/citations/19648967 | http://www.w3.org/2000/01/rdf-schema#comment | "LYRIC/AEG-1 and its altered expression have been linked to carcinogenesis in prostate, brain and melanoma as well as promoting chemoresistance and metastasis in breast cancer. LYRIC/AEG-1 function remains unclear, although LYRIC/AEG-1 is activated by oncogenic HA-RAS, through binding of c-myc to its promoter, which in turn regulates the key components of the PI3-kinase and nuclear factor-kappaB pathways. We have identified the transcriptional repressor PLZF as an interacting protein of LYRIC/AEG through a yeast two-hybrid screen. PLZF regulates the expression of genes involved in cell growth and apoptosis including c-myc. Coexpression of LYRIC/AEG-1 with PLZF leads to a reduction in PLZF-mediated repression by reducing PLZF binding to promoters. We have confirmed that nuclear LYRIC/AEG-1 and PLZF interact in mammalian cells via the N- and C termini of LYRIC/AEG-1 and a region C terminal to the RD2 domain of PLZF. Both proteins colocalize to nuclear bodies containing histone deacetylases, which are known to promote PLZF-mediated repression. Our data suggest one mechanism for cells with altered LYRIC/AEG-1 expression to evade apoptosis and increase cell growth during tumourigenesis through the regulation of PLZF repression."xsd:string |
| http://purl.uniprot.org/citations/19648967 | http://purl.org/dc/terms/identifier | "doi:10.1038/onc.2009.223"xsd:string |
| http://purl.uniprot.org/citations/19648967 | http://purl.uniprot.org/core/author | "Mills I.G."xsd:string |
| http://purl.uniprot.org/citations/19648967 | http://purl.uniprot.org/core/author | "Neal D.E."xsd:string |
| http://purl.uniprot.org/citations/19648967 | http://purl.uniprot.org/core/author | "Whitaker H.C."xsd:string |
| http://purl.uniprot.org/citations/19648967 | http://purl.uniprot.org/core/author | "Thirkettle H.J."xsd:string |
| http://purl.uniprot.org/citations/19648967 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19648967 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/19648967 | http://purl.uniprot.org/core/pages | "3663-3670"xsd:string |
| http://purl.uniprot.org/citations/19648967 | http://purl.uniprot.org/core/title | "Nuclear LYRIC/AEG-1 interacts with PLZF and relieves PLZF-mediated repression."xsd:string |
| http://purl.uniprot.org/citations/19648967 | http://purl.uniprot.org/core/volume | "28"xsd:string |
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