| http://purl.uniprot.org/citations/19683501 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19683501 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19683501 | http://www.w3.org/2000/01/rdf-schema#comment | "Proteins that bind to single-stranded DNA (ssDNA) are essential for DNA replication, recombinational repair, and maintenance of genomic stability. Here, we describe the characterization of an ssDNA-binding heterotrimeric complex, SOSS (sensor of ssDNA) in human, which consists of human SSB homologs hSSB1/2 (SOSS-B1/2) and INTS3 (SOSS-A) and a previously uncharacterized protein C9orf80 (SOSS-C). We have shown that SOSS-A serves as a central adaptor required not only for SOSS complex assembly and stability, but also for facilitating the accumulation of SOSS complex to DNA ends. Moreover, SOSS-depleted cells display increased ionizing radiation sensitivity, defective G2/M checkpoint, and impaired homologous recombination repair. Thus, our study defines a pathway involving the sensing of ssDNA by SOSS complex and suggests that this SOSS complex is likely involved in the maintenance of genome stability."xsd:string |
| http://purl.uniprot.org/citations/19683501 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2009.06.011"xsd:string |
| http://purl.uniprot.org/citations/19683501 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2009.06.011"xsd:string |
| http://purl.uniprot.org/citations/19683501 | http://purl.uniprot.org/core/author | "Chen J."xsd:string |
| http://purl.uniprot.org/citations/19683501 | http://purl.uniprot.org/core/author | "Chen J."xsd:string |
| http://purl.uniprot.org/citations/19683501 | http://purl.uniprot.org/core/author | "Gong Z."xsd:string |
| http://purl.uniprot.org/citations/19683501 | http://purl.uniprot.org/core/author | "Gong Z."xsd:string |
| http://purl.uniprot.org/citations/19683501 | http://purl.uniprot.org/core/author | "Huang J."xsd:string |
| http://purl.uniprot.org/citations/19683501 | http://purl.uniprot.org/core/author | "Huang J."xsd:string |
| http://purl.uniprot.org/citations/19683501 | http://purl.uniprot.org/core/author | "Ghosal G."xsd:string |
| http://purl.uniprot.org/citations/19683501 | http://purl.uniprot.org/core/author | "Ghosal G."xsd:string |
| http://purl.uniprot.org/citations/19683501 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19683501 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19683501 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/19683501 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/19683501 | http://purl.uniprot.org/core/pages | "384-393"xsd:string |
| http://purl.uniprot.org/citations/19683501 | http://purl.uniprot.org/core/pages | "384-393"xsd:string |
| http://purl.uniprot.org/citations/19683501 | http://purl.uniprot.org/core/title | "SOSS complexes participate in the maintenance of genomic stability."xsd:string |
| http://purl.uniprot.org/citations/19683501 | http://purl.uniprot.org/core/title | "SOSS complexes participate in the maintenance of genomic stability."xsd:string |
| http://purl.uniprot.org/citations/19683501 | http://purl.uniprot.org/core/volume | "35"xsd:string |
| http://purl.uniprot.org/citations/19683501 | http://purl.uniprot.org/core/volume | "35"xsd:string |
| http://purl.uniprot.org/citations/19683501 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19683501 |
| http://purl.uniprot.org/citations/19683501 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19683501 |