| http://purl.uniprot.org/citations/19703902 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19703902 | http://www.w3.org/2000/01/rdf-schema#comment | "Parkinson disease (PD) is caused by loss of dopamine, which is synthesized from tyrosine by two enzymes, tyrosine hydroxylase (TH) and 4-dihydroxy-L-phenylalanine decarboxylase (DDC). DJ-1 is a causative gene for the familial form of PD, but little is known about the roles of DJ-1 in dopamine synthesis. In this study, we found that DJ-1 directly bound to TH and DDC and positively regulated their activities in human dopaminergic cells. Mutants of DJ-1 found in PD patients, including heterozygous mutants, lost their activity and worked as dominant-negative forms toward wild-type DJ-1. When cells were treated with H(2)O(2), 6-hydroxydopamine, or 1-methyl-4-phenylpyridinium, changes in activities of TH and DDC accompanied by oxidation of cysteine 106 of DJ-1 occurred. It was found that DJ-1 possessing Cys-106 with SH and SOH forms was active and that DJ-1 possessing Cys-106 with SO(2)H and SO(3)H forms was inactive in terms of stimulation of TH and DDC activities. These findings indicate an essential role of DJ-1 in dopamine synthesis and contribution of DJ-1 to the sporadic form of PD."xsd:string |
| http://purl.uniprot.org/citations/19703902 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m109.019950"xsd:string |
| http://purl.uniprot.org/citations/19703902 | http://purl.uniprot.org/core/author | "Ishikawa S."xsd:string |
| http://purl.uniprot.org/citations/19703902 | http://purl.uniprot.org/core/author | "Ariga H."xsd:string |
| http://purl.uniprot.org/citations/19703902 | http://purl.uniprot.org/core/author | "Niki T."xsd:string |
| http://purl.uniprot.org/citations/19703902 | http://purl.uniprot.org/core/author | "Iguchi-Ariga S.M."xsd:string |
| http://purl.uniprot.org/citations/19703902 | http://purl.uniprot.org/core/author | "Taira T."xsd:string |
| http://purl.uniprot.org/citations/19703902 | http://purl.uniprot.org/core/author | "Takahashi-Niki K."xsd:string |
| http://purl.uniprot.org/citations/19703902 | http://purl.uniprot.org/core/author | "Maita H."xsd:string |
| http://purl.uniprot.org/citations/19703902 | http://purl.uniprot.org/core/author | "Maita C."xsd:string |
| http://purl.uniprot.org/citations/19703902 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19703902 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/19703902 | http://purl.uniprot.org/core/pages | "28832-28844"xsd:string |
| http://purl.uniprot.org/citations/19703902 | http://purl.uniprot.org/core/title | "Oxidative status of DJ-1-dependent activation of dopamine synthesis through interaction of tyrosine hydroxylase and 4-dihydroxy-L-phenylalanine (L-DOPA) decarboxylase with DJ-1."xsd:string |
| http://purl.uniprot.org/citations/19703902 | http://purl.uniprot.org/core/volume | "284"xsd:string |
| http://purl.uniprot.org/citations/19703902 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19703902 |
| http://purl.uniprot.org/citations/19703902 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19703902 |
| http://purl.uniprot.org/uniprot/P20711#attribution-7A89C856D48D0DF739760A1FE9BA65F3 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19703902 |
| http://purl.uniprot.org/uniprot/P20711#attribution-85B5E506B0FA04A2584B2CEB5382B896 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19703902 |
| http://purl.uniprot.org/uniprot/Q99497#attribution-7A89C856D48D0DF739760A1FE9BA65F3 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19703902 |
| http://purl.uniprot.org/uniprot/Q99497#attribution-85B5E506B0FA04A2584B2CEB5382B896 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19703902 |
| http://purl.uniprot.org/uniprot/P07101#attribution-7A89C856D48D0DF739760A1FE9BA65F3 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19703902 |
| http://purl.uniprot.org/uniprot/#_A0A087WV24-mappedCitation-19703902 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19703902 |
| http://purl.uniprot.org/uniprot/#_Q15587-mappedCitation-19703902 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19703902 |