| http://purl.uniprot.org/citations/19755138 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19755138 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19755138 | http://www.w3.org/2000/01/rdf-schema#comment | "Oestrogen receptor related proteins (ERRs) affect target gene expression without binding oestradiol. We investigated the functional activity of two splice variant isoforms of ERR beta (ERR beta S [short], ERR beta L [long]) expressed in human endometrium, where they are coexpressed with the oestrogen receptor alpha (ER alpha). Over-expression of ERRbetaL enhanced ER alpha-dependent ligand-induced activation of an ERE-luciferase reporter construct, altered the induction of c-myc mRNA and increased proliferation of Ishikawa cells whereas ERR beta S was found to reduce these endpoints. Fluorescent recovery after photobleaching (FRAP) revealed that intra-nuclear mobility of YFP-ERR beta S was more rapid than YFP-ERR beta L. Fluorescence resonance energy transfer (FRET) assays revealed a close association between ERR beta L and ER alpha following addition of ligand. We speculate that ERR beta L may alter ER alpha-dependent gene activation by enhancing the recruitment of co-activators. In conclusion, variant isoforms of ERR beta have differential effects on ER alpha-dependent gene expression and this has implications for human endometrial cell function."xsd:string |
| http://purl.uniprot.org/citations/19755138 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.mce.2009.09.007"xsd:string |
| http://purl.uniprot.org/citations/19755138 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.mce.2009.09.007"xsd:string |
| http://purl.uniprot.org/citations/19755138 | http://purl.uniprot.org/core/author | "Collins F."xsd:string |
| http://purl.uniprot.org/citations/19755138 | http://purl.uniprot.org/core/author | "Collins F."xsd:string |
| http://purl.uniprot.org/citations/19755138 | http://purl.uniprot.org/core/author | "Saunders P.T."xsd:string |
| http://purl.uniprot.org/citations/19755138 | http://purl.uniprot.org/core/author | "Saunders P.T."xsd:string |
| http://purl.uniprot.org/citations/19755138 | http://purl.uniprot.org/core/author | "Brown P."xsd:string |
| http://purl.uniprot.org/citations/19755138 | http://purl.uniprot.org/core/author | "Brown P."xsd:string |
| http://purl.uniprot.org/citations/19755138 | http://purl.uniprot.org/core/author | "Bombail V."xsd:string |
| http://purl.uniprot.org/citations/19755138 | http://purl.uniprot.org/core/author | "Bombail V."xsd:string |
| http://purl.uniprot.org/citations/19755138 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/19755138 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/19755138 | http://purl.uniprot.org/core/name | "Mol. Cell. Endocrinol."xsd:string |
| http://purl.uniprot.org/citations/19755138 | http://purl.uniprot.org/core/name | "Mol. Cell. Endocrinol."xsd:string |
| http://purl.uniprot.org/citations/19755138 | http://purl.uniprot.org/core/pages | "53-61"xsd:string |
| http://purl.uniprot.org/citations/19755138 | http://purl.uniprot.org/core/pages | "53-61"xsd:string |
| http://purl.uniprot.org/citations/19755138 | http://purl.uniprot.org/core/title | "Modulation of ER alpha transcriptional activity by the orphan nuclear receptor ERR beta and evidence for differential effects of long- and short-form splice variants."xsd:string |
| http://purl.uniprot.org/citations/19755138 | http://purl.uniprot.org/core/title | "Modulation of ER alpha transcriptional activity by the orphan nuclear receptor ERR beta and evidence for differential effects of long- and short-form splice variants."xsd:string |
| http://purl.uniprot.org/citations/19755138 | http://purl.uniprot.org/core/volume | "314"xsd:string |
| http://purl.uniprot.org/citations/19755138 | http://purl.uniprot.org/core/volume | "314"xsd:string |
| http://purl.uniprot.org/citations/19755138 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19755138 |
| http://purl.uniprot.org/citations/19755138 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19755138 |