| http://purl.uniprot.org/citations/19756449 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19756449 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19756449 | http://www.w3.org/2000/01/rdf-schema#comment | "Serum and glucocorticoid regulated kinase 1 (Sgk1) is a serine-threonine kinase that is activated by serum, steroids, insulin, vasopressin, and interleukin 2 at the transcriptional and post-translational levels. Sgk1 is also important in transduction of growth factors and steroid-dependent survival signals and may have a role in the development of resistance to cancer chemotherapy. In the present paper, we demonstrate that Sgk1 activates MDM2-dependent p53 ubiquitylation. The results were obtained in RKO cells and other cell lines by Sgk1-specific RNA silencing and were corroborated in an original mouse model as well as in transiently and in stably transfected HeLa cells expressing wild-type or dominant negative Sgk1 mutant. Sgk1 contributes to cell survival, cell-cycle progression, and epithelial de-differentiation. We also show that the effects of Sgk1 on the clonogenic potential of different cancer cells depend on the expression of wild-type p53. Since transcription of Sgk1 is activated by p53, we propose a finely tuned feedback model where Sgk1 down-regulates the expression of p53 by enhancing its mono- and polyubiquitylation."xsd:string |
| http://purl.uniprot.org/citations/19756449 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00109-009-0525-5"xsd:string |
| http://purl.uniprot.org/citations/19756449 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00109-009-0525-5"xsd:string |
| http://purl.uniprot.org/citations/19756449 | http://purl.uniprot.org/core/author | "Lang F."xsd:string |
| http://purl.uniprot.org/citations/19756449 | http://purl.uniprot.org/core/author | "Lang F."xsd:string |
| http://purl.uniprot.org/citations/19756449 | http://purl.uniprot.org/core/author | "Soddu S."xsd:string |
| http://purl.uniprot.org/citations/19756449 | http://purl.uniprot.org/core/author | "Soddu S."xsd:string |
| http://purl.uniprot.org/citations/19756449 | http://purl.uniprot.org/core/author | "Bellacchio E."xsd:string |
| http://purl.uniprot.org/citations/19756449 | http://purl.uniprot.org/core/author | "Bellacchio E."xsd:string |
| http://purl.uniprot.org/citations/19756449 | http://purl.uniprot.org/core/author | "Perrotti N."xsd:string |
| http://purl.uniprot.org/citations/19756449 | http://purl.uniprot.org/core/author | "Perrotti N."xsd:string |
| http://purl.uniprot.org/citations/19756449 | http://purl.uniprot.org/core/author | "Paggi M.G."xsd:string |
| http://purl.uniprot.org/citations/19756449 | http://purl.uniprot.org/core/author | "Paggi M.G."xsd:string |
| http://purl.uniprot.org/citations/19756449 | http://purl.uniprot.org/core/author | "Agosti V."xsd:string |
| http://purl.uniprot.org/citations/19756449 | http://purl.uniprot.org/core/author | "Agosti V."xsd:string |
| http://purl.uniprot.org/citations/19756449 | http://purl.uniprot.org/core/author | "Menniti M."xsd:string |
| http://purl.uniprot.org/citations/19756449 | http://purl.uniprot.org/core/author | "Menniti M."xsd:string |
| http://purl.uniprot.org/citations/19756449 | http://purl.uniprot.org/core/author | "Costa N."xsd:string |
| http://purl.uniprot.org/citations/19756449 | http://purl.uniprot.org/core/author | "Costa N."xsd:string |
| http://purl.uniprot.org/citations/19756449 | http://purl.uniprot.org/core/author | "Amato R."xsd:string |
| http://purl.uniprot.org/citations/19756449 | http://purl.uniprot.org/core/author | "Amato R."xsd:string |
| http://purl.uniprot.org/citations/19756449 | http://purl.uniprot.org/core/author | "D'Antona L."xsd:string |
| http://purl.uniprot.org/citations/19756449 | http://purl.uniprot.org/core/author | "D'Antona L."xsd:string |