| http://purl.uniprot.org/citations/19779455 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19779455 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19779455 | http://www.w3.org/2000/01/rdf-schema#comment | "Heat shock and other environmental stresses rapidly induce transcriptional responses subject to regulation by a variety of post-translational modifications. Among these, poly(ADP-ribosyl)ation and sumoylation have received growing attention. Here we show that the SUMO E3 ligase PIASy interacts with the poly(ADP-ribose) polymerase PARP-1, and that PIASy mediates heat shock-induced poly-sumoylation of PARP-1. Furthermore, PIASy, and hence sumoylation, appears indispensable for full activation of the inducible HSP70.1 gene. Chromatin immunoprecipitation experiments show that PIASy, SUMO and the SUMO-conjugating enzyme Ubc9 are rapidly recruited to the HSP70.1 promoter upon heat shock, and that they are subsequently released with kinetics similar to PARP-1. Finally, we provide evidence that the SUMO-targeted ubiquitin ligase RNF4 mediates heat-shock-inducible ubiquitination of PARP-1, regulates the stability of PARP-1, and, like PIASy, is a positive regulator of HSP70.1 gene activity. These results, thus, point to a novel mechanism for regulating PARP-1 transcription function, and suggest crosstalk between sumoylation and RNF4-mediated ubiquitination in regulating gene expression in response to heat shock."xsd:string |
| http://purl.uniprot.org/citations/19779455 | http://purl.org/dc/terms/identifier | "doi:10.1038/emboj.2009.279"xsd:string |
| http://purl.uniprot.org/citations/19779455 | http://purl.org/dc/terms/identifier | "doi:10.1038/emboj.2009.279"xsd:string |
| http://purl.uniprot.org/citations/19779455 | http://purl.uniprot.org/core/author | "Martin N."xsd:string |
| http://purl.uniprot.org/citations/19779455 | http://purl.uniprot.org/core/author | "Martin N."xsd:string |
| http://purl.uniprot.org/citations/19779455 | http://purl.uniprot.org/core/author | "Dejean A."xsd:string |
| http://purl.uniprot.org/citations/19779455 | http://purl.uniprot.org/core/author | "Dejean A."xsd:string |
| http://purl.uniprot.org/citations/19779455 | http://purl.uniprot.org/core/author | "Werner A."xsd:string |
| http://purl.uniprot.org/citations/19779455 | http://purl.uniprot.org/core/author | "Werner A."xsd:string |
| http://purl.uniprot.org/citations/19779455 | http://purl.uniprot.org/core/author | "Seeler J.S."xsd:string |
| http://purl.uniprot.org/citations/19779455 | http://purl.uniprot.org/core/author | "Seeler J.S."xsd:string |
| http://purl.uniprot.org/citations/19779455 | http://purl.uniprot.org/core/author | "Zhang X.D."xsd:string |
| http://purl.uniprot.org/citations/19779455 | http://purl.uniprot.org/core/author | "Zhang X.D."xsd:string |
| http://purl.uniprot.org/citations/19779455 | http://purl.uniprot.org/core/author | "Schreiber V."xsd:string |
| http://purl.uniprot.org/citations/19779455 | http://purl.uniprot.org/core/author | "Schreiber V."xsd:string |
| http://purl.uniprot.org/citations/19779455 | http://purl.uniprot.org/core/author | "Bischof O."xsd:string |
| http://purl.uniprot.org/citations/19779455 | http://purl.uniprot.org/core/author | "Bischof O."xsd:string |
| http://purl.uniprot.org/citations/19779455 | http://purl.uniprot.org/core/author | "Schwamborn K."xsd:string |
| http://purl.uniprot.org/citations/19779455 | http://purl.uniprot.org/core/author | "Schwamborn K."xsd:string |
| http://purl.uniprot.org/citations/19779455 | http://purl.uniprot.org/core/author | "Guillier C."xsd:string |
| http://purl.uniprot.org/citations/19779455 | http://purl.uniprot.org/core/author | "Guillier C."xsd:string |
| http://purl.uniprot.org/citations/19779455 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19779455 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |