| http://purl.uniprot.org/citations/19782034 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19782034 | http://www.w3.org/2000/01/rdf-schema#comment | "Previous studies have suggested that the HIF transcription factors can both activate and inhibit gene expression. Here we show that HIF1 regulates the expression of mir-210 in a variety of tumor types through a hypoxia-responsive element. Expression analysis in primary head and neck tumor samples indicates that mir-210 may serve as an in vivo marker for tumor hypoxia. By Argonaute protein immunoprecipitation, we identified 50 potential mir-210 targets and validated randomly selected ones. The majority of these 50 genes are not classical hypoxia-inducible genes, suggesting mir-210 represses genes expressed under normoxia that are no longer necessary to adapt and survive in a hypoxic environment. When human head and neck or pancreatic tumor cells ectopically expressing mir-210 were implanted into immunodeficient mice, mir-210 repressed initiation of tumor growth. Taken together, these data implicate an important role for mir-210 in regulating the hypoxic response of tumor cells and tumor growth."xsd:string |
| http://purl.uniprot.org/citations/19782034 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2009.09.006"xsd:string |
| http://purl.uniprot.org/citations/19782034 | http://purl.uniprot.org/core/author | "Ding L."xsd:string |
| http://purl.uniprot.org/citations/19782034 | http://purl.uniprot.org/core/author | "Huang X."xsd:string |
| http://purl.uniprot.org/citations/19782034 | http://purl.uniprot.org/core/author | "Ang K.K."xsd:string |
| http://purl.uniprot.org/citations/19782034 | http://purl.uniprot.org/core/author | "Giaccia A.J."xsd:string |
| http://purl.uniprot.org/citations/19782034 | http://purl.uniprot.org/core/author | "Le Q.T."xsd:string |
| http://purl.uniprot.org/citations/19782034 | http://purl.uniprot.org/core/author | "Welford S.M."xsd:string |
| http://purl.uniprot.org/citations/19782034 | http://purl.uniprot.org/core/author | "Story M."xsd:string |
| http://purl.uniprot.org/citations/19782034 | http://purl.uniprot.org/core/author | "Bennewith K.L."xsd:string |
| http://purl.uniprot.org/citations/19782034 | http://purl.uniprot.org/core/author | "Tong R.T."xsd:string |
| http://purl.uniprot.org/citations/19782034 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19782034 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/19782034 | http://purl.uniprot.org/core/pages | "856-867"xsd:string |
| http://purl.uniprot.org/citations/19782034 | http://purl.uniprot.org/core/title | "Hypoxia-inducible mir-210 regulates normoxic gene expression involved in tumor initiation."xsd:string |
| http://purl.uniprot.org/citations/19782034 | http://purl.uniprot.org/core/volume | "35"xsd:string |
| http://purl.uniprot.org/citations/19782034 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19782034 |
| http://purl.uniprot.org/citations/19782034 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19782034 |
| http://purl.uniprot.org/uniprot/Q16665#attribution-093E02B2C6F31799262D9599D107BDF1 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19782034 |
| http://purl.uniprot.org/uniprot/#_D0VY79-mappedCitation-19782034 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19782034 |
| http://purl.uniprot.org/uniprot/#_P0C5Y9-mappedCitation-19782034 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19782034 |
| http://purl.uniprot.org/uniprot/#_P10276-mappedCitation-19782034 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19782034 |
| http://purl.uniprot.org/uniprot/#_P57053-mappedCitation-19782034 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19782034 |
| http://purl.uniprot.org/uniprot/#_B2R617-mappedCitation-19782034 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19782034 |