| http://purl.uniprot.org/citations/19820710 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19820710 | http://www.w3.org/2000/01/rdf-schema#comment | "Targeted gene silencing by RNA interference (RNAi) requires loading of a short guide RNA (small interfering RNA (siRNA) or microRNA (miRNA)) onto an Argonaute protein to form the functional center of an RNA-induced silencing complex (RISC). In humans, Argonaute2 (AGO2) assembles with the guide RNA-generating enzyme Dicer and the RNA-binding protein TRBP to form a RISC-loading complex (RLC), which is necessary for efficient transfer of nascent siRNAs and miRNAs from Dicer to AGO2. Here, using single-particle EM analysis, we show that human Dicer has an L-shaped structure. The RLC Dicer's N-terminal DExH/D domain, located in a short 'base branch', interacts with TRBP, whereas its C-terminal catalytic domains in the main body are proximal to AGO2. A model generated by docking the available atomic structures of Dicer and Argonaute homologs into the RLC reconstruction suggests a mechanism for siRNA transfer from Dicer to AGO2."xsd:string |
| http://purl.uniprot.org/citations/19820710 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb.1673"xsd:string |
| http://purl.uniprot.org/citations/19820710 | http://purl.uniprot.org/core/author | "Doudna J.A."xsd:string |
| http://purl.uniprot.org/citations/19820710 | http://purl.uniprot.org/core/author | "Ma E."xsd:string |
| http://purl.uniprot.org/citations/19820710 | http://purl.uniprot.org/core/author | "Nogales E."xsd:string |
| http://purl.uniprot.org/citations/19820710 | http://purl.uniprot.org/core/author | "Wang H.W."xsd:string |
| http://purl.uniprot.org/citations/19820710 | http://purl.uniprot.org/core/author | "Taylor D.W."xsd:string |
| http://purl.uniprot.org/citations/19820710 | http://purl.uniprot.org/core/author | "Felderer K."xsd:string |
| http://purl.uniprot.org/citations/19820710 | http://purl.uniprot.org/core/author | "Siridechadilok B."xsd:string |
| http://purl.uniprot.org/citations/19820710 | http://purl.uniprot.org/core/author | "Noland C."xsd:string |
| http://purl.uniprot.org/citations/19820710 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19820710 | http://purl.uniprot.org/core/name | "Nat Struct Mol Biol"xsd:string |
| http://purl.uniprot.org/citations/19820710 | http://purl.uniprot.org/core/pages | "1148-1153"xsd:string |
| http://purl.uniprot.org/citations/19820710 | http://purl.uniprot.org/core/title | "Structural insights into RNA processing by the human RISC-loading complex."xsd:string |
| http://purl.uniprot.org/citations/19820710 | http://purl.uniprot.org/core/volume | "16"xsd:string |
| http://purl.uniprot.org/citations/19820710 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19820710 |
| http://purl.uniprot.org/citations/19820710 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19820710 |
| http://purl.uniprot.org/uniprot/Q15633#attribution-A613CF8738AA401CB81CAFB5781A1DBF | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19820710 |
| http://purl.uniprot.org/uniprot/#_Q15633-mappedCitation-19820710 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19820710 |
| http://purl.uniprot.org/uniprot/#_A8K3X2-mappedCitation-19820710 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19820710 |
| http://purl.uniprot.org/uniprot/#_B7Z1P5-mappedCitation-19820710 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19820710 |
| http://purl.uniprot.org/uniprot/#_A4FVC0-mappedCitation-19820710 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19820710 |
| http://purl.uniprot.org/uniprot/#_Q9UKV8-mappedCitation-19820710 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19820710 |
| http://purl.uniprot.org/uniprot/Q15633 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19820710 |