| http://purl.uniprot.org/citations/19825650 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19825650 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19825650 | http://www.w3.org/2000/01/rdf-schema#comment | "In Arabidopsis, pericentromeric repeats, retroelements, and silenced rRNA genes are assembled into heterochromatin within nuclear structures known as chromocenters. The mechanisms governing higher-order heterochromatin organization are poorly understood but 24-nt small interfering RNAs (siRNAs) are known to play key roles in heterochromatin formation. Nuclear RNA polymerase IV (Pol IV), RNA-DEPENDENT RNA POLYMERASE 2 (RDR2), and DICER-LIKE 3 (DCL3) are required for biogenesis of 24-nt siRNAs that associate with ARGONAUTE 4 (AGO4). Nuclear RNA polymerase V (Pol V) collaborates with DRD1 (DEFICIENT IN RNA-DEPENDENT DNA METHYLATION 1) to generate transcripts at heterochromatic loci that are hypothesized to bind to siRNA-AGO4 complexes and subsequently recruit the de-novo DNA methylation and/or histone modifying machinery. Here, we report that decondensation of the major pericentromeric repeats and depletion of the heterochromatic mark histone H3 lysine 9 dimethylation at chromocenters occurs specifically in pol V and drd1 mutants. Disruption of pericentromeric repeats condensation is coincident with transcriptional reactivation of specific classes of pericentromeric 180-bp repeats. We further demonstrate that Pol V functions independently of Pol IV, RDR2, and DCL3-mediated siRNA production to affect interphase heterochromatin organization, possibly by involving RNAs that recruit structural or chromatin-modifying proteins."xsd:string |
| http://purl.uniprot.org/citations/19825650 | http://purl.org/dc/terms/identifier | "doi:10.1093/mp/ssp006"xsd:string |
| http://purl.uniprot.org/citations/19825650 | http://purl.org/dc/terms/identifier | "doi:10.1093/mp/ssp006"xsd:string |
| http://purl.uniprot.org/citations/19825650 | http://purl.uniprot.org/core/author | "Pikaard C.S."xsd:string |
| http://purl.uniprot.org/citations/19825650 | http://purl.uniprot.org/core/author | "Pikaard C.S."xsd:string |
| http://purl.uniprot.org/citations/19825650 | http://purl.uniprot.org/core/author | "Pontes O."xsd:string |
| http://purl.uniprot.org/citations/19825650 | http://purl.uniprot.org/core/author | "Pontes O."xsd:string |
| http://purl.uniprot.org/citations/19825650 | http://purl.uniprot.org/core/author | "Costa-Nunes P."xsd:string |
| http://purl.uniprot.org/citations/19825650 | http://purl.uniprot.org/core/author | "Costa-Nunes P."xsd:string |
| http://purl.uniprot.org/citations/19825650 | http://purl.uniprot.org/core/author | "Vithayathil P."xsd:string |
| http://purl.uniprot.org/citations/19825650 | http://purl.uniprot.org/core/author | "Vithayathil P."xsd:string |
| http://purl.uniprot.org/citations/19825650 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19825650 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19825650 | http://purl.uniprot.org/core/name | "Mol. Plant"xsd:string |
| http://purl.uniprot.org/citations/19825650 | http://purl.uniprot.org/core/name | "Mol. Plant"xsd:string |
| http://purl.uniprot.org/citations/19825650 | http://purl.uniprot.org/core/pages | "700-710"xsd:string |
| http://purl.uniprot.org/citations/19825650 | http://purl.uniprot.org/core/pages | "700-710"xsd:string |
| http://purl.uniprot.org/citations/19825650 | http://purl.uniprot.org/core/title | "RNA polymerase V functions in Arabidopsis interphase heterochromatin organization independently of the 24-nt siRNA-directed DNA methylation pathway."xsd:string |
| http://purl.uniprot.org/citations/19825650 | http://purl.uniprot.org/core/title | "RNA polymerase V functions in Arabidopsis interphase heterochromatin organization independently of the 24-nt siRNA-directed DNA methylation pathway."xsd:string |
| http://purl.uniprot.org/citations/19825650 | http://purl.uniprot.org/core/volume | "2"xsd:string |
| http://purl.uniprot.org/citations/19825650 | http://purl.uniprot.org/core/volume | "2"xsd:string |
| http://purl.uniprot.org/citations/19825650 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19825650 |
| http://purl.uniprot.org/citations/19825650 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19825650 |