| http://purl.uniprot.org/citations/19841752 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19841752 | http://www.w3.org/2000/01/rdf-schema#comment | "gammadelta T cells play an important role in regulating the immune response to stress stimuli; however, the mean by which these innate lymphocytes fulfill this function remains poorly defined. The main subset of human peripheral blood gammadelta T cells responds to nonpeptidic antigens, such as isopentylpyrophosphate (IPP), a metabolite in the mevalonate pathway for both eukaryote and prokaryote cells. IPP-primed gammadelta T cells significantly augment the inflammatory response mediated by monocytes and alphabeta T cells to TSST-1, the staphylococcal superantigen that is the major causative agent of toxic shock syndrome. Here we show that the small pool of activated peripheral gammadelta T cells induces an early upregulation of CD40 on monocytes and the local release of High Mobility Group Box-1 (HMGB-1), the molecule designated as the late mediator of systemic inflammation. This finding provides a new basis for how gammadelta T cells may serve as influential modulators of both endogenous and exogenous stress stimuli."xsd:string |
| http://purl.uniprot.org/citations/19841752 | http://purl.org/dc/terms/identifier | "doi:10.1155/2009/819408"xsd:string |
| http://purl.uniprot.org/citations/19841752 | http://purl.uniprot.org/core/author | "Chow A.W."xsd:string |
| http://purl.uniprot.org/citations/19841752 | http://purl.uniprot.org/core/author | "Kalyan S."xsd:string |
| http://purl.uniprot.org/citations/19841752 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19841752 | http://purl.uniprot.org/core/name | "Mediators Inflamm"xsd:string |
| http://purl.uniprot.org/citations/19841752 | http://purl.uniprot.org/core/pages | "819408"xsd:string |
| http://purl.uniprot.org/citations/19841752 | http://purl.uniprot.org/core/title | "Linking innate and adaptive immunity: human Vgamma9Vdelta2 T cells enhance CD40 expression and HMGB-1 secretion."xsd:string |
| http://purl.uniprot.org/citations/19841752 | http://purl.uniprot.org/core/volume | "2009"xsd:string |
| http://purl.uniprot.org/citations/19841752 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19841752 |
| http://purl.uniprot.org/citations/19841752 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19841752 |
| http://purl.uniprot.org/uniprot/P09429#attribution-29A3AA252E47D89C48F19212618BA517 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19841752 |
| http://purl.uniprot.org/uniprot/P09429#attribution-2D7B48CED76F18B75FAF32D305B4632B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19841752 |