| http://purl.uniprot.org/citations/19858209 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19858209 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19858209 | http://www.w3.org/2000/01/rdf-schema#comment | "We have identified G protein suppressor 2 (GPS2) as a stable component of the SMRT corepressor complexes. GPS2 potently represses basal transcription, with the repression domain mapped to the N-terminal silencing mediator of retinoic acid and thyroid hormone receptor (SMRT)-interacting domain. Knockdown of GPS2 abrogates, whereas overexpression potentiates, SMRT-mediated repression activity. The SMRT complexes are involved in 4-hydroxyl-tamoxifen (4OHT)-mediated gene repression by estrogen receptor alpha (ERalpha). We show that 4OHT recruits SMRT and GPS2 to the promoter of pS2, an ERalpha target gene, in a dynamic manner. Unexpectedly, we also found that estradiol (E2) promotes promoter recruitment of the SMRT complexes. While knockdown of GPS2 compromised 4OHT-mediated repression, it enhanced E2-induced expression of a reporter gene and several endogenous ERalpha target genes, including pS2, cyclin D1 (CCND1), progesterone receptor (PR), and c-MYC. Finally, we show that depletion of GPS2 or SMRT by siRNA promotes cell proliferation in MCF-7 breast cancer cells. Thus, we concluded that GPS2 is an integral component of the SMRT complexes, important for ligand-dependent gene regulations by ERalpha and a suppressor for MCF-7 cell proliferation."xsd:string |
| http://purl.uniprot.org/citations/19858209 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m109.062109"xsd:string |
| http://purl.uniprot.org/citations/19858209 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m109.062109"xsd:string |
| http://purl.uniprot.org/citations/19858209 | http://purl.uniprot.org/core/author | "Cheng X."xsd:string |
| http://purl.uniprot.org/citations/19858209 | http://purl.uniprot.org/core/author | "Cheng X."xsd:string |
| http://purl.uniprot.org/citations/19858209 | http://purl.uniprot.org/core/author | "Kao H.Y."xsd:string |
| http://purl.uniprot.org/citations/19858209 | http://purl.uniprot.org/core/author | "Kao H.Y."xsd:string |
| http://purl.uniprot.org/citations/19858209 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19858209 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19858209 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/19858209 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/19858209 | http://purl.uniprot.org/core/pages | "36395-36404"xsd:string |
| http://purl.uniprot.org/citations/19858209 | http://purl.uniprot.org/core/pages | "36395-36404"xsd:string |
| http://purl.uniprot.org/citations/19858209 | http://purl.uniprot.org/core/title | "G protein pathway suppressor 2 (GPS2) is a transcriptional corepressor important for estrogen receptor alpha-mediated transcriptional regulation."xsd:string |
| http://purl.uniprot.org/citations/19858209 | http://purl.uniprot.org/core/title | "G protein pathway suppressor 2 (GPS2) is a transcriptional corepressor important for estrogen receptor alpha-mediated transcriptional regulation."xsd:string |
| http://purl.uniprot.org/citations/19858209 | http://purl.uniprot.org/core/volume | "284"xsd:string |
| http://purl.uniprot.org/citations/19858209 | http://purl.uniprot.org/core/volume | "284"xsd:string |
| http://purl.uniprot.org/citations/19858209 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19858209 |
| http://purl.uniprot.org/citations/19858209 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19858209 |
| http://purl.uniprot.org/citations/19858209 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19858209 |
| http://purl.uniprot.org/citations/19858209 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19858209 |
| http://purl.uniprot.org/uniprot/Q9Y618 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/19858209 |
| http://purl.uniprot.org/uniprot/Q13227 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/19858209 |