| http://purl.uniprot.org/citations/19888548 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19888548 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19888548 | http://www.w3.org/2000/01/rdf-schema#comment | "The histone chaperone nucleosome assembly protein, hNAP-1, is a host cofactor for the activity of the human immunodeficiency virus type 1 (HIV-1) transactivator Tat. The interaction between these two proteins has been shown to be important for Tat-mediated transcriptional activation and for efficient viral infection. Visualization of HIV-1 transcription and fluorescence resonance energy transfer experiments performed in this work demonstrate that hNAP-1 is not recruited to the site of Tat activity but the two proteins interact at the nuclear rim. These data are consistent with a mechanism that requires hNAP-1 for the transport of Tat within the nucleus rather than for the remodeling of nucleosomes on the provirus. Protein-protein docking and molecular modeling of the complex suggest that this interaction occurs between the basic domain of Tat and the histone-binding domain. The combination of theoretical and whole cell studies provided new insights into the functional significance of the Tat:hNAP-1 recognition."xsd:string |
| http://purl.uniprot.org/citations/19888548 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00726-009-0378-9"xsd:string |
| http://purl.uniprot.org/citations/19888548 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00726-009-0378-9"xsd:string |
| http://purl.uniprot.org/citations/19888548 | http://purl.uniprot.org/core/author | "De Marco A."xsd:string |
| http://purl.uniprot.org/citations/19888548 | http://purl.uniprot.org/core/author | "De Marco A."xsd:string |
| http://purl.uniprot.org/citations/19888548 | http://purl.uniprot.org/core/author | "Dans P.D."xsd:string |
| http://purl.uniprot.org/citations/19888548 | http://purl.uniprot.org/core/author | "Dans P.D."xsd:string |
| http://purl.uniprot.org/citations/19888548 | http://purl.uniprot.org/core/author | "Knezevich A."xsd:string |
| http://purl.uniprot.org/citations/19888548 | http://purl.uniprot.org/core/author | "Knezevich A."xsd:string |
| http://purl.uniprot.org/citations/19888548 | http://purl.uniprot.org/core/author | "Maiuri P."xsd:string |
| http://purl.uniprot.org/citations/19888548 | http://purl.uniprot.org/core/author | "Maiuri P."xsd:string |
| http://purl.uniprot.org/citations/19888548 | http://purl.uniprot.org/core/author | "Marcello A."xsd:string |
| http://purl.uniprot.org/citations/19888548 | http://purl.uniprot.org/core/author | "Marcello A."xsd:string |
| http://purl.uniprot.org/citations/19888548 | http://purl.uniprot.org/core/author | "Pantano S."xsd:string |
| http://purl.uniprot.org/citations/19888548 | http://purl.uniprot.org/core/author | "Pantano S."xsd:string |
| http://purl.uniprot.org/citations/19888548 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/19888548 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/19888548 | http://purl.uniprot.org/core/name | "Amino Acids"xsd:string |
| http://purl.uniprot.org/citations/19888548 | http://purl.uniprot.org/core/name | "Amino Acids"xsd:string |
| http://purl.uniprot.org/citations/19888548 | http://purl.uniprot.org/core/pages | "1583-1593"xsd:string |
| http://purl.uniprot.org/citations/19888548 | http://purl.uniprot.org/core/pages | "1583-1593"xsd:string |
| http://purl.uniprot.org/citations/19888548 | http://purl.uniprot.org/core/title | "Subcellular localization of the interaction between the human immunodeficiency virus transactivator Tat and the nucleosome assembly protein 1."xsd:string |
| http://purl.uniprot.org/citations/19888548 | http://purl.uniprot.org/core/title | "Subcellular localization of the interaction between the human immunodeficiency virus transactivator Tat and the nucleosome assembly protein 1."xsd:string |