| http://purl.uniprot.org/citations/19928958 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19928958 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19928958 | http://www.w3.org/2000/01/rdf-schema#comment | "The duck-billed platypus (Ornithorhynchus anatinus) is one of the few venomous Australian mammals. We previously found that its crude venom potently induces Ca(2+) influx in human neuroblastoma IMR-32 cells. Guided by this bioassay, we identified 11 novel peptides, including the heptapeptide H-His-Asp-His-Pro-Asn-Pro-Arg-OH (1). Compounds 1-4 and 5-11 coincided with the 6-9 N-terminal residues of Ornithorhynchus venom C-type natriuretic peptide (OvCNP) and the 132-150 part of OvCNP precursor peptide, respectively. Heptapeptide 1, which is one of the primary components of the venom fluid (approximately 200 ng/microL), induced a significant increase in [Ca(2+)](i) in IMR-32 cells at 75 microM. To the best of our knowledge, this is the first example of the isolation of the N-terminal linear fragments of CNPs in any mammal."xsd:string |
| http://purl.uniprot.org/citations/19928958 | http://purl.org/dc/terms/identifier | "doi:10.1021/ja908148z"xsd:string |
| http://purl.uniprot.org/citations/19928958 | http://purl.org/dc/terms/identifier | "doi:10.1021/ja908148z"xsd:string |
| http://purl.uniprot.org/citations/19928958 | http://purl.uniprot.org/core/author | "Yamada K."xsd:string |
| http://purl.uniprot.org/citations/19928958 | http://purl.uniprot.org/core/author | "Yamada K."xsd:string |
| http://purl.uniprot.org/citations/19928958 | http://purl.uniprot.org/core/author | "Black D.S."xsd:string |
| http://purl.uniprot.org/citations/19928958 | http://purl.uniprot.org/core/author | "Black D.S."xsd:string |
| http://purl.uniprot.org/citations/19928958 | http://purl.uniprot.org/core/author | "Kigoshi H."xsd:string |
| http://purl.uniprot.org/citations/19928958 | http://purl.uniprot.org/core/author | "Kigoshi H."xsd:string |
| http://purl.uniprot.org/citations/19928958 | http://purl.uniprot.org/core/author | "Kita M."xsd:string |
| http://purl.uniprot.org/citations/19928958 | http://purl.uniprot.org/core/author | "Kita M."xsd:string |
| http://purl.uniprot.org/citations/19928958 | http://purl.uniprot.org/core/author | "Ohno O."xsd:string |
| http://purl.uniprot.org/citations/19928958 | http://purl.uniprot.org/core/author | "Ohno O."xsd:string |
| http://purl.uniprot.org/citations/19928958 | http://purl.uniprot.org/core/author | "Uemura D."xsd:string |
| http://purl.uniprot.org/citations/19928958 | http://purl.uniprot.org/core/author | "Uemura D."xsd:string |
| http://purl.uniprot.org/citations/19928958 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19928958 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19928958 | http://purl.uniprot.org/core/name | "J. Am. Chem. Soc."xsd:string |
| http://purl.uniprot.org/citations/19928958 | http://purl.uniprot.org/core/name | "J. Am. Chem. Soc."xsd:string |
| http://purl.uniprot.org/citations/19928958 | http://purl.uniprot.org/core/pages | "18038-18039"xsd:string |
| http://purl.uniprot.org/citations/19928958 | http://purl.uniprot.org/core/pages | "18038-18039"xsd:string |
| http://purl.uniprot.org/citations/19928958 | http://purl.uniprot.org/core/title | "Duck-billed platypus venom peptides induce Ca2+ influx in neuroblastoma cells."xsd:string |
| http://purl.uniprot.org/citations/19928958 | http://purl.uniprot.org/core/title | "Duck-billed platypus venom peptides induce Ca2+ influx in neuroblastoma cells."xsd:string |