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| http://purl.uniprot.org/citations/19931242 | http://www.w3.org/2000/01/rdf-schema#comment | "Angiocidin, a matrix bound and tumor associated protein, has been shown to inhibit tumor progression and angiogenesis. We previously demonstrated that angiocidin binds to thrombospondin-1 and alpha2beta1 integrin. We now show that angiocidin binds and is a preferred substrate for tissue transglutaminase-2 (tTgase). Angiocidin bound tTgase saturably with a Kd of 26 nM, while an angiocidin deletion mutant missing the matrix binding domain of angiocidin failed to bind tTgase. tTgase colocalized with angiocidin on endothelial cells. tTgase bound anti-angiocidin immunoprecipitates of endothelial cell lysates. Breast cancer cells expressing high levels of tTgase attached to angiocidin immobilized on tissue culture plates. Angiocidin was a preferred substrate for tTgase forming high molecular weight cross-linked multimers when treated with tTgase. Cross-linked angiocidin contained iso-peptide bonds as demonstrated by Western blotting and immunohistochemical colocalization studies using endothelial cells treated with angiocidin. Cross-linked angiocidin inhibited cell migration in contrast to monomeric angiocidin and inhibited localization of fibronectin (FN), a pro-tumorigenic matrix protein, into the extracellular matrix (ECM) of tumor and HUVE cells. Our studies provide an additional explanation for the anti-tumor activity of angiocidin suggesting that cross-linked angiocidin disrupts the tumor ECM making it less permissive for tumor growth."xsd:string |
| http://purl.uniprot.org/citations/19931242 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.yexmp.2009.11.001"xsd:string |
| http://purl.uniprot.org/citations/19931242 | http://purl.uniprot.org/core/author | "Rothman V.L."xsd:string |
| http://purl.uniprot.org/citations/19931242 | http://purl.uniprot.org/core/author | "Tuszynski G.P."xsd:string |
| http://purl.uniprot.org/citations/19931242 | http://purl.uniprot.org/core/author | "L'Heureux D.Z."xsd:string |
| http://purl.uniprot.org/citations/19931242 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/19931242 | http://purl.uniprot.org/core/name | "Exp Mol Pathol"xsd:string |
| http://purl.uniprot.org/citations/19931242 | http://purl.uniprot.org/core/pages | "15-25"xsd:string |
| http://purl.uniprot.org/citations/19931242 | http://purl.uniprot.org/core/title | "The interaction of angiocidin with tissue transglutaminase."xsd:string |
| http://purl.uniprot.org/citations/19931242 | http://purl.uniprot.org/core/volume | "88"xsd:string |
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