| http://purl.uniprot.org/citations/19937655 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19937655 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19937655 | http://www.w3.org/2000/01/rdf-schema#comment | "The Mapkap kinases 2 and 3 (MK2 and MK3) have been implicated in intracellular signaling pathways leading to the production of the pro-inflammatory cytokine tumor necrosis factor alpha. MK2 has been pursued by the biopharmaceutical industry for many years for the development of a small molecule anti-inflammatory treatment and drug-like inhibitors have been described. The development of some of these compounds, however, has been slowed by the absence of a high-resolution crystal structure of MK2. Herein we present a high-resolution (1.9 A) crystal structure of the highly homologous MK3 in complex with a pharmaceutical lead compound. While all of the canonical features of Ser/Thr kinases in general and MK2 in particular are recapitulated in MK3, the detailed analysis of the binding interaction of the drug-like ligand within the adenine binding pocket allows relevant conclusions to be drawn for the further design of potent and selective drug candidates."xsd:string |
| http://purl.uniprot.org/citations/19937655 | http://purl.org/dc/terms/identifier | "doi:10.1002/pro.294"xsd:string |
| http://purl.uniprot.org/citations/19937655 | http://purl.org/dc/terms/identifier | "doi:10.1002/pro.294"xsd:string |
| http://purl.uniprot.org/citations/19937655 | http://purl.uniprot.org/core/author | "Whittaker M."xsd:string |
| http://purl.uniprot.org/citations/19937655 | http://purl.uniprot.org/core/author | "Whittaker M."xsd:string |
| http://purl.uniprot.org/citations/19937655 | http://purl.uniprot.org/core/author | "Barker J."xsd:string |
| http://purl.uniprot.org/citations/19937655 | http://purl.uniprot.org/core/author | "Barker J."xsd:string |
| http://purl.uniprot.org/citations/19937655 | http://purl.uniprot.org/core/author | "Felicetti B."xsd:string |
| http://purl.uniprot.org/citations/19937655 | http://purl.uniprot.org/core/author | "Felicetti B."xsd:string |
| http://purl.uniprot.org/citations/19937655 | http://purl.uniprot.org/core/author | "Scheich C."xsd:string |
| http://purl.uniprot.org/citations/19937655 | http://purl.uniprot.org/core/author | "Scheich C."xsd:string |
| http://purl.uniprot.org/citations/19937655 | http://purl.uniprot.org/core/author | "Cheng R."xsd:string |
| http://purl.uniprot.org/citations/19937655 | http://purl.uniprot.org/core/author | "Cheng R."xsd:string |
| http://purl.uniprot.org/citations/19937655 | http://purl.uniprot.org/core/author | "Hesterkamp T."xsd:string |
| http://purl.uniprot.org/citations/19937655 | http://purl.uniprot.org/core/author | "Hesterkamp T."xsd:string |
| http://purl.uniprot.org/citations/19937655 | http://purl.uniprot.org/core/author | "Palan S."xsd:string |
| http://purl.uniprot.org/citations/19937655 | http://purl.uniprot.org/core/author | "Palan S."xsd:string |
| http://purl.uniprot.org/citations/19937655 | http://purl.uniprot.org/core/author | "Toogood-Johnson I."xsd:string |
| http://purl.uniprot.org/citations/19937655 | http://purl.uniprot.org/core/author | "Toogood-Johnson I."xsd:string |
| http://purl.uniprot.org/citations/19937655 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/19937655 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/19937655 | http://purl.uniprot.org/core/name | "Protein Sci."xsd:string |
| http://purl.uniprot.org/citations/19937655 | http://purl.uniprot.org/core/name | "Protein Sci."xsd:string |