| http://purl.uniprot.org/citations/19948887 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19948887 | http://www.w3.org/2000/01/rdf-schema#comment | "Spt4-Spt5, a general transcription elongation factor for RNA polymerase II, also has roles in chromatin regulation. However, the relationships between these functions are not clear. Previously, we isolated suppressors of a Saccharomyces cerevisiae spt5 mutation in genes encoding members of the Paf1 complex, which regulates several cotranscriptional histone modifications, and Chd1, a chromatin remodeling enzyme. Here, we show that this suppression of spt5 can result from loss of histone H3 lysines 4 or 36 methylation, or reduced recruitment of Chd1 or the Rpd3S complex. These spt5 suppressors also rescue the synthetic growth defects observed in spt5 mutants that also lack elongation factor TFIIS. Using a FLO8 reporter gene, we found that a chd1 mutation caused cryptic initiation of transcription. We further observed enhancement of cryptic initiation in chd1 isw1 mutants and increased histone acetylation in a chd1 mutant. We suggest that, as previously proposed for H3 lysine 36 methylation and the Rpd3S complex, H3 lysine 4 methylation and Chd1 function to maintain normal chromatin structures over transcribed genes, and that one function of Spt4-Spt5 is to help RNA polymerase II overcome the repressive effects of these histone modifications and chromatin regulators on transcription."xsd:string |
| http://purl.uniprot.org/citations/19948887 | http://purl.org/dc/terms/identifier | "doi:10.1534/genetics.109.111526"xsd:string |
| http://purl.uniprot.org/citations/19948887 | http://purl.uniprot.org/core/author | "Hartzog G.A."xsd:string |
| http://purl.uniprot.org/citations/19948887 | http://purl.uniprot.org/core/author | "Quan T.K."xsd:string |
| http://purl.uniprot.org/citations/19948887 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/19948887 | http://purl.uniprot.org/core/name | "Genetics"xsd:string |
| http://purl.uniprot.org/citations/19948887 | http://purl.uniprot.org/core/pages | "321-334"xsd:string |
| http://purl.uniprot.org/citations/19948887 | http://purl.uniprot.org/core/title | "Histone H3K4 and K36 methylation, Chd1 and Rpd3S oppose the functions of Saccharomyces cerevisiae Spt4-Spt5 in transcription."xsd:string |
| http://purl.uniprot.org/citations/19948887 | http://purl.uniprot.org/core/volume | "184"xsd:string |
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