| http://purl.uniprot.org/citations/20007743 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20007743 | http://www.w3.org/2000/01/rdf-schema#comment | "Most membrane proteins are recognized by a signal recognition particle and are cotranslationally targeted to the endoplasmic reticulum (ER) membrane, whereas almost all peroxisomal membrane proteins are posttranslationally targeted to the destination. Here we examined organelle-targeting properties of the N-terminal portions of the peroxisomal isoform of the ABC transporter PMP70 (ABCD3) using enhanced green fluorescent protein (EGFP) fusion. When the N-terminal 80 amino acid residue (N80)-segment preceding transmembrane segment (TM) 1 was deleted and the TM1-TM2 region was fused to EGFP, the TM1 segment induced ER-targeting and integration in COS cells. When the N80-segment was fused to EGFP, the fusion protein was targeted to the outer mitochondrial membrane. When both the N80-segment and the following TM1-TM2 region were present, the fusion located exclusively to the peroxisome. The full-length PMP70 molecule was clearly located in the ER in the absence of the N80-segment, even when multiple peroxisome-targeting signals were retained. We concluded that the TM1 segment possesses a sufficient ER-targeting function and that the N80-segment is critical for suppressing the ER-targeting function to allow the TM1-TM2 region to localize to the peroxisome. Cooperation of the organelle-targeting signals enables PMP70 to correctly target to peroxisomal membranes."xsd:string |
| http://purl.uniprot.org/citations/20007743 | http://purl.org/dc/terms/identifier | "doi:10.1093/jb/mvp205"xsd:string |
| http://purl.uniprot.org/citations/20007743 | http://purl.uniprot.org/core/author | "Imanaka T."xsd:string |
| http://purl.uniprot.org/citations/20007743 | http://purl.uniprot.org/core/author | "Sakaguchi M."xsd:string |
| http://purl.uniprot.org/citations/20007743 | http://purl.uniprot.org/core/author | "Yamashita Y."xsd:string |
| http://purl.uniprot.org/citations/20007743 | http://purl.uniprot.org/core/author | "Emi Y."xsd:string |
| http://purl.uniprot.org/citations/20007743 | http://purl.uniprot.org/core/author | "Kida Y."xsd:string |
| http://purl.uniprot.org/citations/20007743 | http://purl.uniprot.org/core/author | "Tsuchida M."xsd:string |
| http://purl.uniprot.org/citations/20007743 | http://purl.uniprot.org/core/author | "Kashiwayama Y."xsd:string |
| http://purl.uniprot.org/citations/20007743 | http://purl.uniprot.org/core/author | "Iwashita S."xsd:string |
| http://purl.uniprot.org/citations/20007743 | http://purl.uniprot.org/core/author | "Tsukuda M."xsd:string |
| http://purl.uniprot.org/citations/20007743 | http://purl.uniprot.org/core/author | "Komori M."xsd:string |
| http://purl.uniprot.org/citations/20007743 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20007743 | http://purl.uniprot.org/core/name | "J Biochem"xsd:string |
| http://purl.uniprot.org/citations/20007743 | http://purl.uniprot.org/core/pages | "581-590"xsd:string |
| http://purl.uniprot.org/citations/20007743 | http://purl.uniprot.org/core/title | "Multiple organelle-targeting signals in the N-terminal portion of peroxisomal membrane protein PMP70."xsd:string |
| http://purl.uniprot.org/citations/20007743 | http://purl.uniprot.org/core/volume | "147"xsd:string |
| http://purl.uniprot.org/citations/20007743 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20007743 |
| http://purl.uniprot.org/citations/20007743 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20007743 |
| http://purl.uniprot.org/uniprot/Q62760#attribution-D6C69A7179CCC5D4CF6FAAD6F4EF3958 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20007743 |
| http://purl.uniprot.org/uniprot/#_A0A8I6AHS7-mappedCitation-20007743 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20007743 |
| http://purl.uniprot.org/uniprot/#_B4DL07-mappedCitation-20007743 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20007743 |
| http://purl.uniprot.org/uniprot/#_B4DZ22-mappedCitation-20007743 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20007743 |
| http://purl.uniprot.org/uniprot/#_Q71V77-mappedCitation-20007743 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20007743 |