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http://purl.uniprot.org/citations/20007824http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/20007824http://www.w3.org/2000/01/rdf-schema#comment"

Purpose

To study associations of small, hard macular drusen and peripheral drusen with genotypes associated with age-related macular degeneration (AMD).

Methods

Digital grayscale fundus photographs recorded in red-free illumination were graded for the presence of drusen in 1107 subjects aged 30 to 66 years. Participants were genotyped for AMD-related polymorphisms in complement factor H (CFH), in LOC387715, and in complement factor B (CFB).

Results

The prevalence of 20 or more small, hard macular drusen per eye was 14%, with no association to the investigated polymorphisms. Peripheral drusen were associated with CFHY402H (odds ratio [OR], 4.3; 95% confidence interval [95% CI], 1.4-13, for CC versus TT genotypes) as was macular drusen >63 microm (OR, 1.9; 95% CI, 1.1-3.1, for CC versus TT genotypes). Macular drusen >63 microm were associated with the presence of 20 or more small, hard macular drusen (OR, 1.7; 95% CI, 1.1-2.6) and with peripheral drusen (OR, 2.5; 95% CI,1.2-5.4)

Conclusions

In this study, the presence of 20 or more small, hard macular drusen per eye was not associated with known AMD-related polymorphisms, whereas the study confirmed an association of peripheral drusen with CFHY402H. (ClinicalTrials.gov number, NCT00289237)."xsd:string
http://purl.uniprot.org/citations/20007824http://purl.org/dc/terms/identifier"doi:10.1167/iovs.09-4482"xsd:string
http://purl.uniprot.org/citations/20007824http://purl.uniprot.org/core/author"Larsen M."xsd:string
http://purl.uniprot.org/citations/20007824http://purl.uniprot.org/core/author"Sander B."xsd:string
http://purl.uniprot.org/citations/20007824http://purl.uniprot.org/core/author"Brondum-Nielsen K."xsd:string
http://purl.uniprot.org/citations/20007824http://purl.uniprot.org/core/author"Ek J."xsd:string
http://purl.uniprot.org/citations/20007824http://purl.uniprot.org/core/author"Linneberg A."xsd:string
http://purl.uniprot.org/citations/20007824http://purl.uniprot.org/core/author"Almind G.J."xsd:string
http://purl.uniprot.org/citations/20007824http://purl.uniprot.org/core/author"Kessel L."xsd:string
http://purl.uniprot.org/citations/20007824http://purl.uniprot.org/core/author"Munch I.C."xsd:string
http://purl.uniprot.org/citations/20007824http://purl.uniprot.org/core/date"2010"xsd:gYear
http://purl.uniprot.org/citations/20007824http://purl.uniprot.org/core/name"Invest Ophthalmol Vis Sci"xsd:string
http://purl.uniprot.org/citations/20007824http://purl.uniprot.org/core/pages"2317-2321"xsd:string
http://purl.uniprot.org/citations/20007824http://purl.uniprot.org/core/title"Small, hard macular drusen and peripheral drusen: associations with AMD genotypes in the Inter99 Eye Study."xsd:string
http://purl.uniprot.org/citations/20007824http://purl.uniprot.org/core/volume"51"xsd:string
http://purl.uniprot.org/citations/20007824http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/20007824
http://purl.uniprot.org/citations/20007824http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/20007824
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