DESCRIBE <http://purl.uniprot.org/citations/20007915>

Subject	Predicate	Object
http://purl.uniprot.org/citations/20007915	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/20007915	http://www.w3.org/2000/01/rdf-schema#comment	" Rationale The Notch signaling pathway is important for cell-cell communication that controls tissue formation and homeostasis during embryonic and adult life, but the precise cell targets of Notch signaling in the mammalian heart remain poorly defined. Objective To investigate the functional role of Notch signaling in the cardiomyocyte compartment of the embryonic and adult heart. Methods and results Here, we report that either conditional overexpression of Notch1 intracellular domain (NICD1) or selective silencing of Notch signaling in the embryonic cardiomyocyte compartment results in developmental defects and perinatal lethality. In contrast, augmentation of endogenous Notch reactivation after myocardial infarction in the adult, either by inducing cardiomyocyte-specific Notch1 transgene expression or by intramyocardial delivery of a Notch1 pseudoligand, increases survival rate, improves cardiac functional performance, and minimizes fibrosis, promoting antiapoptotic and angiogenic mechanisms. Conclusions These results reveal a strict requirement for cell-autonomous modulation of Notch signaling during heart morphogenesis, and illustrate how the same signaling pathway that promotes congenital heart defects when perturbed in the embryo can be therapeutically redeployed for the treatment of adult myocardial damage."xsd:string
http://purl.uniprot.org/citations/20007915	http://purl.org/dc/terms/identifier	"doi:10.1161/circresaha.109.203034"xsd:string
http://purl.uniprot.org/citations/20007915	http://purl.uniprot.org/core/author	"Mourkioti F."xsd:string
http://purl.uniprot.org/citations/20007915	http://purl.uniprot.org/core/author	"Kratsios P."xsd:string
http://purl.uniprot.org/citations/20007915	http://purl.uniprot.org/core/author	"Rosenthal N."xsd:string
http://purl.uniprot.org/citations/20007915	http://purl.uniprot.org/core/author	"Salimova E."xsd:string
http://purl.uniprot.org/citations/20007915	http://purl.uniprot.org/core/author	"Berno V."xsd:string
http://purl.uniprot.org/citations/20007915	http://purl.uniprot.org/core/author	"Catela C."xsd:string
http://purl.uniprot.org/citations/20007915	http://purl.uniprot.org/core/author	"Huth M."xsd:string
http://purl.uniprot.org/citations/20007915	http://purl.uniprot.org/core/date	"2010"xsd:gYear
http://purl.uniprot.org/citations/20007915	http://purl.uniprot.org/core/name	"Circ Res"xsd:string
http://purl.uniprot.org/citations/20007915	http://purl.uniprot.org/core/pages	"559-572"xsd:string
http://purl.uniprot.org/citations/20007915	http://purl.uniprot.org/core/title	"Distinct roles for cell-autonomous Notch signaling in cardiomyocytes of the embryonic and adult heart."xsd:string
http://purl.uniprot.org/citations/20007915	http://purl.uniprot.org/core/volume	"106"xsd:string
http://purl.uniprot.org/citations/20007915	http://www.w3.org/2004/02/skos/core#exactMatch	http://purl.uniprot.org/pubmed/20007915
http://purl.uniprot.org/citations/20007915	http://xmlns.com/foaf/0.1/primaryTopicOf	https://pubmed.ncbi.nlm.nih.gov/20007915
http://purl.uniprot.org/uniprot/Q01705#attribution-20B1D5B466D760B3890FC5EFDACB7AB9	http://purl.uniprot.org/core/source	http://purl.uniprot.org/citations/20007915
http://purl.uniprot.org/uniprot/#_A0A286YDF7-mappedCitation-20007915	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/20007915
http://purl.uniprot.org/uniprot/#_A0A140LIU2-mappedCitation-20007915	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/20007915
http://purl.uniprot.org/uniprot/#_A2A7P3-mappedCitation-20007915	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/20007915
http://purl.uniprot.org/uniprot/#_A4K4Z6-mappedCitation-20007915	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/20007915
http://purl.uniprot.org/uniprot/#_A0A494B983-mappedCitation-20007915	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/20007915
http://purl.uniprot.org/uniprot/#_A0A2I3BPY4-mappedCitation-20007915	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/20007915
http://purl.uniprot.org/uniprot/#_A0A494B9T3-mappedCitation-20007915	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/20007915