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http://purl.uniprot.org/citations/20031597http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/20031597http://www.w3.org/2000/01/rdf-schema#comment"

Background

Growth-differentiation factor-15 (GDF-15) is a stress-responsive transforming growth factor-beta-related cytokine that has emerged as a prognostic biomarker in acute coronary syndrome trial populations. Its predictive role in stable coronary heart disease (CHD) has never been assessed.

Methods and results

The circulating levels of GDF-15 were measured by immunoradiometric assay in patients with stable angina pectoris (n=1352) or acute coronary syndrome (n=877) who were followed up for a median of 3.6 years. Stable angina pectoris patients presenting with normal (<1200 ng/L), moderately elevated (1200 to 1800 ng/L), or markedly elevated (>1800 ng/L) GDF-15 levels had 3.6-year CHD mortality rates of 1.4%, 2.7%, and 15.0%, respectively (P<0.001). By backward stepwise Cox-regression analysis, which adjusted for age and gender, clinical variables, the number of diseased vessels, renal function, the levels of C-reactive protein, cardiac troponin I, and N-terminal pro-B-type natriuretic peptide, GDF-15 remained an independent predictor of CHD mortality (P<0.001). Addition of GDF-15 improved the prognostic accuracy of a clinical risk prediction model concerning CHD mortality (c-statistic, 0.84 versus 0.74; P=0.005). Analysis of the acute coronary syndrome part of the study population confirmed GDF-15 as an independent predictor of CHD mortality (P<0.001). The circulating levels of GDF-15 did not predict the future risk of nonfatal myocardial infarction in patients with stable angina pectoris or acute coronary syndrome.

Conclusions

This study identifies GDF-15 as a strong and independent predictor of CHD mortality across the broad spectrum of patients with stable and unstable CHD."xsd:string
http://purl.uniprot.org/citations/20031597http://purl.org/dc/terms/identifier"doi:10.1161/circgenetics.108.824870"xsd:string
http://purl.uniprot.org/citations/20031597http://purl.uniprot.org/core/author"Kempf T."xsd:string
http://purl.uniprot.org/citations/20031597http://purl.uniprot.org/core/author"Schnabel R."xsd:string
http://purl.uniprot.org/citations/20031597http://purl.uniprot.org/core/author"Quint A."xsd:string
http://purl.uniprot.org/citations/20031597http://purl.uniprot.org/core/author"Blankenberg S."xsd:string
http://purl.uniprot.org/citations/20031597http://purl.uniprot.org/core/author"Drexler H."xsd:string
http://purl.uniprot.org/citations/20031597http://purl.uniprot.org/core/author"Wollert K.C."xsd:string
http://purl.uniprot.org/citations/20031597http://purl.uniprot.org/core/author"Bickel C."xsd:string
http://purl.uniprot.org/citations/20031597http://purl.uniprot.org/core/author"Wild P.S."xsd:string
http://purl.uniprot.org/citations/20031597http://purl.uniprot.org/core/author"Munzel T."xsd:string
http://purl.uniprot.org/citations/20031597http://purl.uniprot.org/core/author"Rupprecht H.J."xsd:string
http://purl.uniprot.org/citations/20031597http://purl.uniprot.org/core/author"Lubos E."xsd:string
http://purl.uniprot.org/citations/20031597http://purl.uniprot.org/core/author"Sinning C."xsd:string
http://purl.uniprot.org/citations/20031597http://purl.uniprot.org/core/author"Sinning J.M."xsd:string
http://purl.uniprot.org/citations/20031597http://purl.uniprot.org/core/date"2009"xsd:gYear
http://purl.uniprot.org/citations/20031597http://purl.uniprot.org/core/name"Circ Cardiovasc Genet"xsd:string
http://purl.uniprot.org/citations/20031597http://purl.uniprot.org/core/pages"286-292"xsd:string
http://purl.uniprot.org/citations/20031597http://purl.uniprot.org/core/title"Growth-differentiation factor-15 for risk stratification in patients with stable and unstable coronary heart disease: results from the AtheroGene study."xsd:string
http://purl.uniprot.org/citations/20031597http://purl.uniprot.org/core/volume"2"xsd:string
http://purl.uniprot.org/citations/20031597http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/20031597
http://purl.uniprot.org/citations/20031597http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/20031597
http://purl.uniprot.org/uniprot/#_Q99988-mappedCitation-20031597http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20031597
http://purl.uniprot.org/uniprot/Q99988http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/20031597
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