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| http://purl.uniprot.org/citations/20097766 | http://www.w3.org/2000/01/rdf-schema#comment | "Our previous study demonstrated that transforming growth factor (TGF)-beta activates beta-catenin signaling through Smad3 interaction with beta-catenin in chondrocytes. In the present studies, we further investigated the detailed molecular mechanism of the cross-talk between TGF-beta/Smad3 and Wnt/beta-catenin signaling pathways. We found that C-terminal Smad3 interacted with both the N-terminal region and the middle region of beta-catenin protein in a TGF-beta-dependent manner. Both Smad3 and Smad4 were required for the interaction with beta-catenin and protected beta-catenin from an ubiquitin-proteasome-dependent degradation. In addition, the formation of the Smad3-Smad4-beta-catenin protein complex also mediated beta-catenin nuclear translocation. This Smad3-mediated regulatory mechanism of beta-catenin protein stability enhanced the activity of beta-catenin to activate downstream target genes during chondrogenesis. Our findings demonstrate a novel mechanism between TGF-beta and Wnt/beta-catenin signaling pathways during chondrocyte development."xsd:string |
| http://purl.uniprot.org/citations/20097766 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m109.093526"xsd:string |
| http://purl.uniprot.org/citations/20097766 | http://purl.uniprot.org/core/author | "Chen D."xsd:string |
| http://purl.uniprot.org/citations/20097766 | http://purl.uniprot.org/core/author | "Wang M."xsd:string |
| http://purl.uniprot.org/citations/20097766 | http://purl.uniprot.org/core/author | "Tan X."xsd:string |
| http://purl.uniprot.org/citations/20097766 | http://purl.uniprot.org/core/author | "Zhang M."xsd:string |
| http://purl.uniprot.org/citations/20097766 | http://purl.uniprot.org/core/author | "Zhang Y.E."xsd:string |
| http://purl.uniprot.org/citations/20097766 | http://purl.uniprot.org/core/author | "Li T.F."xsd:string |
| http://purl.uniprot.org/citations/20097766 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20097766 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/20097766 | http://purl.uniprot.org/core/pages | "8703-8710"xsd:string |
| http://purl.uniprot.org/citations/20097766 | http://purl.uniprot.org/core/title | "Smad3 prevents beta-catenin degradation and facilitates beta-catenin nuclear translocation in chondrocytes."xsd:string |
| http://purl.uniprot.org/citations/20097766 | http://purl.uniprot.org/core/volume | "285"xsd:string |
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