| http://purl.uniprot.org/citations/20125124 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20125124 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin-3 (IL-3) deprivation of the mouse pro-B cell line Ba/F3 induces cell death that is abrogated by B-cell lymphoma 2 (Bcl-2) overexpression, but remains unaffected by the pan-caspase inhibitor carbobenzoxy-valyl-analyl-aspartyl-[O-methyl]-fluoromethylketone (zVAD-fmk). IL-3 withdrawal causes receptor-interacting protein (RIP)1 cleavage into C-terminal fragments of 30 and 25 kDa, and only cleavage leading to the former was prevented by zVAD-fmk. siRNA experiments demonstrated that generation of the 25-kDa fragment was due to a Bcl-2-modulated release of the mitochondrial serine protease high temperature requirement protein A2 (HtrA2)/Omi. Accordingly, recombinant HtrA2/Omi efficiently cleaved mouse RIP1 in vitro, generating fragments matching those observed in IL-3-deprived Ba/F3 cells. The HtrA2/Omi cleavage site in mouse RIP1 was mapped to the intermediate domain and the corresponding N- and C-terminal fragments were impaired in their ability to activate nuclear factor-kappaB, c-Jun N-terminal kinase and p38 mitogen-activated protein kinase. Interestingly, knockdown of HtrA2/Omi afforded protection against IL-3 withdrawal-induced death in the presence of zVAD-fmk, demonstrating a role for HtrA2/Omi in caspase-independent cell death during growth factor withdrawal by cleaving RIP1."xsd:string |
| http://purl.uniprot.org/citations/20125124 | http://purl.org/dc/terms/identifier | "doi:10.1038/cr.2010.18"xsd:string |
| http://purl.uniprot.org/citations/20125124 | http://purl.uniprot.org/core/author | "Saelens X."xsd:string |
| http://purl.uniprot.org/citations/20125124 | http://purl.uniprot.org/core/author | "Vandenabeele P."xsd:string |
| http://purl.uniprot.org/citations/20125124 | http://purl.uniprot.org/core/author | "Wirawan E."xsd:string |
| http://purl.uniprot.org/citations/20125124 | http://purl.uniprot.org/core/author | "Lamkanfi M."xsd:string |
| http://purl.uniprot.org/citations/20125124 | http://purl.uniprot.org/core/author | "Vande Walle L."xsd:string |
| http://purl.uniprot.org/citations/20125124 | http://purl.uniprot.org/core/author | "Vanden Berghe T."xsd:string |
| http://purl.uniprot.org/citations/20125124 | http://purl.uniprot.org/core/author | "Verspurten J."xsd:string |
| http://purl.uniprot.org/citations/20125124 | http://purl.uniprot.org/core/author | "Festjens N."xsd:string |
| http://purl.uniprot.org/citations/20125124 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20125124 | http://purl.uniprot.org/core/name | "Cell Res"xsd:string |
| http://purl.uniprot.org/citations/20125124 | http://purl.uniprot.org/core/pages | "421-433"xsd:string |
| http://purl.uniprot.org/citations/20125124 | http://purl.uniprot.org/core/title | "The mitochondrial serine protease HtrA2/Omi cleaves RIP1 during apoptosis of Ba/F3 cells induced by growth factor withdrawal."xsd:string |
| http://purl.uniprot.org/citations/20125124 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/20125124 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20125124 |
| http://purl.uniprot.org/citations/20125124 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20125124 |
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