| http://purl.uniprot.org/citations/20137943 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20137943 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20137943 | http://www.w3.org/2000/01/rdf-schema#comment | "Through a combination of screening and structure-based rational design, we have discovered a series of N(1)-(5-(heterocyclyl)-thiazol-2-yl)-3-(4-trifluoromethylphenyl)-1,2-propanediamines that were developed into potent ATP competitive inhibitors of AKT. Studies of linker strand-binding adenine isosteres identified SAR trends in potency and selectivity that were consistent with binding interactions observed in structures of the inhibitors bound to AKT1 and to the counter-screening target PKA. One compound was shown to have acceptable pharmacokinetic properties and to be a potent inhibitor of AKT signaling and of in vivo xenograft tumor growth in a preclinical model of glioblastoma."xsd:string |
| http://purl.uniprot.org/citations/20137943 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bmcl.2010.01.067"xsd:string |
| http://purl.uniprot.org/citations/20137943 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bmcl.2010.01.067"xsd:string |
| http://purl.uniprot.org/citations/20137943 | http://purl.uniprot.org/core/author | "Huang X."xsd:string |
| http://purl.uniprot.org/citations/20137943 | http://purl.uniprot.org/core/author | "Huang X."xsd:string |
| http://purl.uniprot.org/citations/20137943 | http://purl.uniprot.org/core/author | "Li C."xsd:string |
| http://purl.uniprot.org/citations/20137943 | http://purl.uniprot.org/core/author | "Li C."xsd:string |
| http://purl.uniprot.org/citations/20137943 | http://purl.uniprot.org/core/author | "Zeng Q."xsd:string |
| http://purl.uniprot.org/citations/20137943 | http://purl.uniprot.org/core/author | "Zeng Q."xsd:string |
| http://purl.uniprot.org/citations/20137943 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/20137943 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/20137943 | http://purl.uniprot.org/core/author | "Zhang S."xsd:string |
| http://purl.uniprot.org/citations/20137943 | http://purl.uniprot.org/core/author | "Zhang S."xsd:string |
| http://purl.uniprot.org/citations/20137943 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/20137943 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/20137943 | http://purl.uniprot.org/core/author | "Yang S."xsd:string |
| http://purl.uniprot.org/citations/20137943 | http://purl.uniprot.org/core/author | "Yang S."xsd:string |
| http://purl.uniprot.org/citations/20137943 | http://purl.uniprot.org/core/author | "Yao G."xsd:string |
| http://purl.uniprot.org/citations/20137943 | http://purl.uniprot.org/core/author | "Yao G."xsd:string |
| http://purl.uniprot.org/citations/20137943 | http://purl.uniprot.org/core/author | "Dominguez C."xsd:string |
| http://purl.uniprot.org/citations/20137943 | http://purl.uniprot.org/core/author | "Dominguez C."xsd:string |
| http://purl.uniprot.org/citations/20137943 | http://purl.uniprot.org/core/author | "Lofgren J.A."xsd:string |
| http://purl.uniprot.org/citations/20137943 | http://purl.uniprot.org/core/author | "Lofgren J.A."xsd:string |