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http://purl.uniprot.org/citations/20138174http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/20138174http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/20138174http://www.w3.org/2000/01/rdf-schema#comment"Epstein-Barr virus latent membrane protein 1 (LMP1) activates NF-kappaB signaling pathways through two C-terminal regions, CTAR1 and CTAR2. Previous studies have demonstrated that BS69, a multidomain cellular protein, regulates LMP1/CTAR2-mediated NF-kappaB activation by interfering with the complex formation between TRADD and LMP1/CTAR2. Here, we found that BS69 directly interacted with the LMP1/CTAR1 domain and regulated LMP1/CTAR1-mediated NF-kappaB activation and subsequent IL-6 production. Regarding the mechanisms involved, we found that BS69 directly interacted with TRAF3, a negative regulator of NF-kappaB activation. Furthermore, small-interfering RNA-mediated knockdown experiments revealed that TRAF3 was involved in the BS69-mediated suppression of LMP1/CTAR1-induced NF-kappaB activation."xsd:string
http://purl.uniprot.org/citations/20138174http://purl.org/dc/terms/identifier"doi:10.1016/j.febslet.2010.01.060"xsd:string
http://purl.uniprot.org/citations/20138174http://purl.org/dc/terms/identifier"doi:10.1016/j.febslet.2010.01.060"xsd:string
http://purl.uniprot.org/citations/20138174http://purl.uniprot.org/core/author"Kuroda M."xsd:string
http://purl.uniprot.org/citations/20138174http://purl.uniprot.org/core/author"Kuroda M."xsd:string
http://purl.uniprot.org/citations/20138174http://purl.uniprot.org/core/author"Fujimuro M."xsd:string
http://purl.uniprot.org/citations/20138174http://purl.uniprot.org/core/author"Fujimuro M."xsd:string
http://purl.uniprot.org/citations/20138174http://purl.uniprot.org/core/author"Matsuda T."xsd:string
http://purl.uniprot.org/citations/20138174http://purl.uniprot.org/core/author"Matsuda T."xsd:string
http://purl.uniprot.org/citations/20138174http://purl.uniprot.org/core/author"Yoshida R."xsd:string
http://purl.uniprot.org/citations/20138174http://purl.uniprot.org/core/author"Yoshida R."xsd:string
http://purl.uniprot.org/citations/20138174http://purl.uniprot.org/core/author"Oritani K."xsd:string
http://purl.uniprot.org/citations/20138174http://purl.uniprot.org/core/author"Oritani K."xsd:string
http://purl.uniprot.org/citations/20138174http://purl.uniprot.org/core/author"Nanbo A."xsd:string
http://purl.uniprot.org/citations/20138174http://purl.uniprot.org/core/author"Nanbo A."xsd:string
http://purl.uniprot.org/citations/20138174http://purl.uniprot.org/core/author"Ikeda O."xsd:string
http://purl.uniprot.org/citations/20138174http://purl.uniprot.org/core/author"Ikeda O."xsd:string
http://purl.uniprot.org/citations/20138174http://purl.uniprot.org/core/author"Miyasaka Y."xsd:string
http://purl.uniprot.org/citations/20138174http://purl.uniprot.org/core/author"Miyasaka Y."xsd:string
http://purl.uniprot.org/citations/20138174http://purl.uniprot.org/core/author"Mizushima A."xsd:string
http://purl.uniprot.org/citations/20138174http://purl.uniprot.org/core/author"Mizushima A."xsd:string
http://purl.uniprot.org/citations/20138174http://purl.uniprot.org/core/author"Muromoto R."xsd:string
http://purl.uniprot.org/citations/20138174http://purl.uniprot.org/core/author"Muromoto R."xsd:string