| http://purl.uniprot.org/citations/20188095 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20188095 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20188095 | http://www.w3.org/2000/01/rdf-schema#comment | "Class IIa histone deacetylases (HDACs) -4, -5, -7 and -9 undergo signal-dependent nuclear export upon phosphorylation of conserved serine residues that are targets for 14-3-3 binding. Little is known of other mechanisms for regulating the subcellular distribution of class IIa HDACs. Using a biochemical purification strategy, we identified protein kinase C-related kinase-2 (PRK2) as an HDAC5-interacting protein. PRK2 and the related kinase, PRK1, phosphorylate HDAC5 at a threonine residue (Thr-292) positioned within the nuclear localization signal (NLS) of the protein. HDAC7 and HDAC9 contain analogous sites that are phosphorylated by PRK, while HDAC4 harbors a non-phosphorylatable alanine residue at this position. We provide evidence to suggest that the unique phospho-acceptor cooperates with the 14-3-3 target sites to impair HDAC nuclear import."xsd:string |
| http://purl.uniprot.org/citations/20188095 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2010.02.057"xsd:string |
| http://purl.uniprot.org/citations/20188095 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2010.02.057"xsd:string |
| http://purl.uniprot.org/citations/20188095 | http://purl.uniprot.org/core/author | "Huynh K."xsd:string |
| http://purl.uniprot.org/citations/20188095 | http://purl.uniprot.org/core/author | "Huynh K."xsd:string |
| http://purl.uniprot.org/citations/20188095 | http://purl.uniprot.org/core/author | "McKinsey T.A."xsd:string |
| http://purl.uniprot.org/citations/20188095 | http://purl.uniprot.org/core/author | "McKinsey T.A."xsd:string |
| http://purl.uniprot.org/citations/20188095 | http://purl.uniprot.org/core/author | "Helmke S.M."xsd:string |
| http://purl.uniprot.org/citations/20188095 | http://purl.uniprot.org/core/author | "Helmke S.M."xsd:string |
| http://purl.uniprot.org/citations/20188095 | http://purl.uniprot.org/core/author | "Perryman M.B."xsd:string |
| http://purl.uniprot.org/citations/20188095 | http://purl.uniprot.org/core/author | "Perryman M.B."xsd:string |
| http://purl.uniprot.org/citations/20188095 | http://purl.uniprot.org/core/author | "Harrison B.C."xsd:string |
| http://purl.uniprot.org/citations/20188095 | http://purl.uniprot.org/core/author | "Harrison B.C."xsd:string |
| http://purl.uniprot.org/citations/20188095 | http://purl.uniprot.org/core/author | "Lundgaard G.L."xsd:string |
| http://purl.uniprot.org/citations/20188095 | http://purl.uniprot.org/core/author | "Lundgaard G.L."xsd:string |
| http://purl.uniprot.org/citations/20188095 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20188095 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20188095 | http://purl.uniprot.org/core/name | "FEBS Lett."xsd:string |
| http://purl.uniprot.org/citations/20188095 | http://purl.uniprot.org/core/name | "FEBS Lett."xsd:string |
| http://purl.uniprot.org/citations/20188095 | http://purl.uniprot.org/core/pages | "1103-1110"xsd:string |
| http://purl.uniprot.org/citations/20188095 | http://purl.uniprot.org/core/pages | "1103-1110"xsd:string |
| http://purl.uniprot.org/citations/20188095 | http://purl.uniprot.org/core/title | "Protein kinase C-related kinase targets nuclear localization signals in a subset of class IIa histone deacetylases."xsd:string |
| http://purl.uniprot.org/citations/20188095 | http://purl.uniprot.org/core/title | "Protein kinase C-related kinase targets nuclear localization signals in a subset of class IIa histone deacetylases."xsd:string |