| http://purl.uniprot.org/citations/20228810 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20228810 | http://www.w3.org/2000/01/rdf-schema#comment | "Actin dynamics is a tightly regulated process involved in various cellular events including biogenesis of clathrin-coated, AP-1 (adaptor protein 1)-coated transport carriers connecting the trans-Golgi network (TGN) and the endocytic pathway. However, the mechanisms coordinating coat assembly, membrane and actin remodelling during post-TGN transport remain poorly understood. Here we show that the Arf1 (ADP-ribosylation factor 1) GTPase synchronizes the TGN association of clathrin-AP-1 coats and protein complexes comprising CYFIP (cytoplasmic fragile-X mental retardation interacting protein; Sra, PIR121), a clathrin heavy chain binding protein associated with mental retardation. The Rac1 GTPase and its exchange factor beta-PIX (PAK-interacting exchange factor) activate these complexes, allowing N-WASP-dependent and Arp2/3-dependent actin polymerization towards membranes, thus promoting tubule formation. These phenomena can be recapitulated with synthetic membranes. This protein-network-based mechanism facilitates the sequential coordination of Arf1-dependent membrane priming, through the recruitment of coats and CYFIP-containing complexes, and of Rac1-dependent actin polymerization, and provides complementary but independent levels of regulation during early stages of clathrin-AP1-coated carrier biogenesis."xsd:string |
| http://purl.uniprot.org/citations/20228810 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb2034"xsd:string |
| http://purl.uniprot.org/citations/20228810 | http://purl.uniprot.org/core/author | "Raposo G."xsd:string |
| http://purl.uniprot.org/citations/20228810 | http://purl.uniprot.org/core/author | "Kirchhausen T."xsd:string |
| http://purl.uniprot.org/citations/20228810 | http://purl.uniprot.org/core/author | "Schenck A."xsd:string |
| http://purl.uniprot.org/citations/20228810 | http://purl.uniprot.org/core/author | "Stange C."xsd:string |
| http://purl.uniprot.org/citations/20228810 | http://purl.uniprot.org/core/author | "Hoflack B."xsd:string |
| http://purl.uniprot.org/citations/20228810 | http://purl.uniprot.org/core/author | "Baust T."xsd:string |
| http://purl.uniprot.org/citations/20228810 | http://purl.uniprot.org/core/author | "Anitei M."xsd:string |
| http://purl.uniprot.org/citations/20228810 | http://purl.uniprot.org/core/author | "Parshina I."xsd:string |
| http://purl.uniprot.org/citations/20228810 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20228810 | http://purl.uniprot.org/core/name | "Nat Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/20228810 | http://purl.uniprot.org/core/pages | "330-340"xsd:string |
| http://purl.uniprot.org/citations/20228810 | http://purl.uniprot.org/core/title | "Protein complexes containing CYFIP/Sra/PIR121 coordinate Arf1 and Rac1 signalling during clathrin-AP-1-coated carrier biogenesis at the TGN."xsd:string |
| http://purl.uniprot.org/citations/20228810 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/20228810 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20228810 |
| http://purl.uniprot.org/citations/20228810 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20228810 |
| http://purl.uniprot.org/uniprot/#_B7Z217-mappedCitation-20228810 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20228810 |
| http://purl.uniprot.org/uniprot/#_B7Z4I3-mappedCitation-20228810 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20228810 |
| http://purl.uniprot.org/uniprot/#_B4DN70-mappedCitation-20228810 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20228810 |
| http://purl.uniprot.org/uniprot/#_B3KWT5-mappedCitation-20228810 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20228810 |
| http://purl.uniprot.org/uniprot/#_B3KWV6-mappedCitation-20228810 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20228810 |
| http://purl.uniprot.org/uniprot/#_B4DEB9-mappedCitation-20228810 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20228810 |
| http://purl.uniprot.org/uniprot/#_B4DJC8-mappedCitation-20228810 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20228810 |