| http://purl.uniprot.org/citations/2023632 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2023632 | http://www.w3.org/2000/01/rdf-schema#comment | "CD43 (sialophorin, leukosialin, leukocyte large sialoglycoprotein), a heavily sialylated molecule found on most leukocytes and platelets, was initially identified as a major glycoprotein of mouse, rat and human T cells. CD43 expression is defective on the T cells of males with the Wiskott-Aldrich syndrome, an X chromosome-linked recessive immunodeficiency disorder. Affected males are susceptible to opportunistic infections and do not respond to polysaccharide antigens, reflecting defects in cytotoxic and helper T-cell functions. Anti-CD43 monoclonal antibodies have a modest costimulatory effect on T cells, natural killer cells, B cells and monocytes, and one such antibody has been shown to activate T cells directly. To investigate a possible physiological role for CD43, a complementary DNA encoding the human protein was introduced into an antigen-responsive murine T-cell hybridoma. We observed that CD43 enhances the antigen-specific activation of T cells and that the intracellular domain of CD43, which is hyperphosphorylated during T-cell activation, is required for this function. We also found that antigen-presenting cells can bind specifically to immobilized purified CD43 and that the binding can be inhibited by liposomes containing CD43 as well as by anti-CD43 monoclonal antibodies."xsd:string |
| http://purl.uniprot.org/citations/2023632 | http://purl.org/dc/terms/identifier | "doi:10.1038/350706a0"xsd:string |
| http://purl.uniprot.org/citations/2023632 | http://purl.uniprot.org/core/author | "Burakoff S.J."xsd:string |
| http://purl.uniprot.org/citations/2023632 | http://purl.uniprot.org/core/author | "Park J.K."xsd:string |
| http://purl.uniprot.org/citations/2023632 | http://purl.uniprot.org/core/author | "Rosen F.S."xsd:string |
| http://purl.uniprot.org/citations/2023632 | http://purl.uniprot.org/core/author | "Bierer B.E."xsd:string |
| http://purl.uniprot.org/citations/2023632 | http://purl.uniprot.org/core/author | "Remold-O'Donnell E."xsd:string |
| http://purl.uniprot.org/citations/2023632 | http://purl.uniprot.org/core/author | "Rosenstein Y.J."xsd:string |
| http://purl.uniprot.org/citations/2023632 | http://purl.uniprot.org/core/date | "1991"xsd:gYear |
| http://purl.uniprot.org/citations/2023632 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/2023632 | http://purl.uniprot.org/core/pages | "706-709"xsd:string |
| http://purl.uniprot.org/citations/2023632 | http://purl.uniprot.org/core/title | "Enhancement of T-cell activation by the CD43 molecule whose expression is defective in Wiskott-Aldrich syndrome."xsd:string |
| http://purl.uniprot.org/citations/2023632 | http://purl.uniprot.org/core/volume | "350"xsd:string |
| http://purl.uniprot.org/citations/2023632 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/2023632 |
| http://purl.uniprot.org/citations/2023632 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/2023632 |
| http://purl.uniprot.org/uniprot/P16150#attribution-30F14B757FEBB112DB6176A9342870A0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/2023632 |