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Background and objectives

Diabetic nephropathy (DN) is a multifactorial complication characterized by persistent proteinuria in susceptible individuals with type 1 and type 2 diabetes. Disease burden in people of Mexican-American descent is particularly high, but there are only a few studies that characterize genes for DN in this ethnic group. Two genes, carnosine dipeptidase 1 (CNDP1) and engulfment and cell motility 1 (ELMO1) previously showed association with DN in other ethnic groups. CNDP1 and ELMO1 were examined along with eight other genes that are less well characterized for DN in a new study of Mexican-Americans.

Design, setting, participants, & measurements

The target sample was patients of Mexican-American ancestry collected from three centers: 455 patients with DN and 437 controls with long-term diabetes but no incident nephropathy. Forty-two, 227, and 401 single nucleotide polymorphisms (SNPs) in CNDP1, ELMO1, and the other eight genes, respectively, were examined.

Results

No region in CNDP1 or ELMO1 showed significant P values. Of the other eight candidate genes, an association of DN with a SNP pair, rs2146098 and rs6659783, was found in hemicentin 1 (HMCN1) (unadjusted P = 6.1 x 10(-5)). Association with a rare haplotype in this region was subsequently identified.

Conclusions

The associations in CNDP1 or ELMO1 were not replicable; however, an association of DN with HMCN1 was found. Additional work at this and other loci will enable refinement of the genetic hypotheses regarding DN in the Mexican-American population to find therapies for this debilitating disease."xsd:string
http://purl.uniprot.org/citations/20299368http://purl.org/dc/terms/identifier"doi:10.2215/cjn.06550909"xsd:string
http://purl.uniprot.org/citations/20299368http://purl.uniprot.org/core/author"Kim S."xsd:string
http://purl.uniprot.org/citations/20299368http://purl.uniprot.org/core/author"Snyder S."xsd:string
http://purl.uniprot.org/citations/20299368http://purl.uniprot.org/core/author"Elston R.C."xsd:string
http://purl.uniprot.org/citations/20299368http://purl.uniprot.org/core/author"Iyengar S.K."xsd:string
http://purl.uniprot.org/citations/20299368http://purl.uniprot.org/core/author"Abboud H.E."xsd:string
http://purl.uniprot.org/citations/20299368http://purl.uniprot.org/core/author"Adler S.G."xsd:string
http://purl.uniprot.org/citations/20299368http://purl.uniprot.org/core/author"Pahl M.V."xsd:string
http://purl.uniprot.org/citations/20299368http://purl.uniprot.org/core/author"Nast C.C."xsd:string
http://purl.uniprot.org/citations/20299368http://purl.uniprot.org/core/author"Ipp E."xsd:string
http://purl.uniprot.org/citations/20299368http://purl.uniprot.org/core/author"Alcorn H. Jr."xsd:string
http://purl.uniprot.org/citations/20299368http://purl.uniprot.org/core/author"Tamkin J."xsd:string
http://purl.uniprot.org/citations/20299368http://purl.uniprot.org/core/author"Tayek J."xsd:string
http://purl.uniprot.org/citations/20299368http://purl.uniprot.org/core/date"2010"xsd:gYear
http://purl.uniprot.org/citations/20299368http://purl.uniprot.org/core/name"Clin J Am Soc Nephrol"xsd:string
http://purl.uniprot.org/citations/20299368http://purl.uniprot.org/core/pages"1072-1078"xsd:string
http://purl.uniprot.org/citations/20299368http://purl.uniprot.org/core/title"Examination of association with candidate genes for diabetic nephropathy in a Mexican American population."xsd:string
http://purl.uniprot.org/citations/20299368http://purl.uniprot.org/core/volume"5"xsd:string
http://purl.uniprot.org/citations/20299368http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/20299368
http://purl.uniprot.org/citations/20299368http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/20299368
http://purl.uniprot.org/uniprot/#_A0A0D9SG88-mappedCitation-20299368http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20299368
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