| http://purl.uniprot.org/citations/20351179 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20351179 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20351179 | http://www.w3.org/2000/01/rdf-schema#comment | "S100 proteins comprise a multigene family of EF-hand calcium binding proteins that engage in multiple functions in response to cellular stress. In one case, the S100B protein has been implicated in oligodendrocyte progenitor cell (OPC) regeneration in response to demyelinating insult. In this example, we report that the mitochondrial ATAD3A protein is a major, high-affinity, and calcium-dependent S100B target protein in OPC. In OPC, ATAD3A is required for cell growth and differentiation. Molecular characterization of the S100B binding domain on ATAD3A by nuclear magnetic resonance (NMR) spectroscopy techniques defined a consensus calcium-dependent S100B binding motif. This S100B binding motif is conserved in several other S100B target proteins, including the p53 protein. Cellular studies using a truncated ATAD3A mutant that is deficient for mitochondrial import revealed that S100B prevents cytoplasmic ATAD3A mutant aggregation and restored its mitochondrial localization. With these results in mind, we propose that S100B could assist the newly synthesized ATAD3A protein, which harbors the consensus S100B binding domain for proper folding and subcellular localization. Such a function for S100B might also help to explain the rescue of nuclear translocation and activation of the temperature-sensitive p53val135 mutant by S100B at nonpermissive temperatures."xsd:string |
| http://purl.uniprot.org/citations/20351179 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.01468-09"xsd:string |
| http://purl.uniprot.org/citations/20351179 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.01468-09"xsd:string |
| http://purl.uniprot.org/citations/20351179 | http://purl.uniprot.org/core/author | "Gilquin B."xsd:string |
| http://purl.uniprot.org/citations/20351179 | http://purl.uniprot.org/core/author | "Gilquin B."xsd:string |
| http://purl.uniprot.org/citations/20351179 | http://purl.uniprot.org/core/author | "Falk E."xsd:string |
| http://purl.uniprot.org/citations/20351179 | http://purl.uniprot.org/core/author | "Falk E."xsd:string |
| http://purl.uniprot.org/citations/20351179 | http://purl.uniprot.org/core/author | "Kieffer S."xsd:string |
| http://purl.uniprot.org/citations/20351179 | http://purl.uniprot.org/core/author | "Kieffer S."xsd:string |
| http://purl.uniprot.org/citations/20351179 | http://purl.uniprot.org/core/author | "Baudier J."xsd:string |
| http://purl.uniprot.org/citations/20351179 | http://purl.uniprot.org/core/author | "Baudier J."xsd:string |
| http://purl.uniprot.org/citations/20351179 | http://purl.uniprot.org/core/author | "Assard N."xsd:string |
| http://purl.uniprot.org/citations/20351179 | http://purl.uniprot.org/core/author | "Assard N."xsd:string |
| http://purl.uniprot.org/citations/20351179 | http://purl.uniprot.org/core/author | "Cannon B.R."xsd:string |
| http://purl.uniprot.org/citations/20351179 | http://purl.uniprot.org/core/author | "Cannon B.R."xsd:string |
| http://purl.uniprot.org/citations/20351179 | http://purl.uniprot.org/core/author | "Hubstenberger A."xsd:string |
| http://purl.uniprot.org/citations/20351179 | http://purl.uniprot.org/core/author | "Hubstenberger A."xsd:string |
| http://purl.uniprot.org/citations/20351179 | http://purl.uniprot.org/core/author | "Merle N."xsd:string |
| http://purl.uniprot.org/citations/20351179 | http://purl.uniprot.org/core/author | "Merle N."xsd:string |
| http://purl.uniprot.org/citations/20351179 | http://purl.uniprot.org/core/author | "Moulouel B."xsd:string |
| http://purl.uniprot.org/citations/20351179 | http://purl.uniprot.org/core/author | "Moulouel B."xsd:string |
| http://purl.uniprot.org/citations/20351179 | http://purl.uniprot.org/core/author | "Rousseau D."xsd:string |
| http://purl.uniprot.org/citations/20351179 | http://purl.uniprot.org/core/author | "Rousseau D."xsd:string |