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http://purl.uniprot.org/citations/20452482http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/20452482http://www.w3.org/2000/01/rdf-schema#comment"

Objective

The purpose of this study was to determine whether maternal/fetal single nucleotide polymorphisms (SNPs) in candidate genes are associated with spontaneous preterm labor/delivery.

Study design

A genetic association study was conducted in 223 mothers and 179 fetuses (preterm labor with intact membranes who delivered <37 weeks of gestation [preterm birth (PTB)]), and 599 mothers and 628 fetuses (normal pregnancy); 190 candidate genes and 775 SNPs were studied. Single locus/haplotype association analyses were performed; the false discovery rate was used to correct for multiple testing.

Results

The strongest single locus associations with PTB were interleukin-6 receptor 1 (fetus; P=.000148) and tissue inhibitor of metalloproteinase 2 (mother; P=.000197), which remained significant after correction for multiple comparisons. Global haplotype analysis indicated an association between a fetal DNA variant in insulin-like growth factor F2 and maternal alpha 3 type IV collagen isoform 1 (global, P=.004 and .007, respectively).

Conclusion

An SNP involved in controlling fetal inflammation (interleukin-6 receptor 1) and DNA variants in maternal genes encoding for proteins involved in extracellular matrix metabolism approximately doubled the risk of PTB."xsd:string
http://purl.uniprot.org/citations/20452482http://purl.org/dc/terms/identifier"doi:10.1016/j.ajog.2010.03.026"xsd:string
http://purl.uniprot.org/citations/20452482http://purl.uniprot.org/core/author"Lee M.S."xsd:string
http://purl.uniprot.org/citations/20452482http://purl.uniprot.org/core/author"Kim C.J."xsd:string
http://purl.uniprot.org/citations/20452482http://purl.uniprot.org/core/author"Williams S.M."xsd:string
http://purl.uniprot.org/citations/20452482http://purl.uniprot.org/core/author"Vovis G.F."xsd:string
http://purl.uniprot.org/citations/20452482http://purl.uniprot.org/core/author"Romero R."xsd:string
http://purl.uniprot.org/citations/20452482http://purl.uniprot.org/core/author"Gomez R."xsd:string
http://purl.uniprot.org/citations/20452482http://purl.uniprot.org/core/author"Bartlett J."xsd:string
http://purl.uniprot.org/citations/20452482http://purl.uniprot.org/core/author"Hassan S.S."xsd:string
http://purl.uniprot.org/citations/20452482http://purl.uniprot.org/core/author"Tromp G."xsd:string
http://purl.uniprot.org/citations/20452482http://purl.uniprot.org/core/author"Velez Edwards D.R."xsd:string
http://purl.uniprot.org/citations/20452482http://purl.uniprot.org/core/author"Salisbury B.A."xsd:string
http://purl.uniprot.org/citations/20452482http://purl.uniprot.org/core/author"Kusanovic J.P."xsd:string
http://purl.uniprot.org/citations/20452482http://purl.uniprot.org/core/author"Menon R."xsd:string
http://purl.uniprot.org/citations/20452482http://purl.uniprot.org/core/author"Behnke E."xsd:string
http://purl.uniprot.org/citations/20452482http://purl.uniprot.org/core/author"Pearce B.D."xsd:string
http://purl.uniprot.org/citations/20452482http://purl.uniprot.org/core/author"Chaiworapongsa T."xsd:string
http://purl.uniprot.org/citations/20452482http://purl.uniprot.org/core/author"Mazaki-Tovi S."xsd:string
http://purl.uniprot.org/citations/20452482http://purl.uniprot.org/core/author"Anant M.K."xsd:string
http://purl.uniprot.org/citations/20452482http://purl.uniprot.org/core/author"Friel L.A."xsd:string
http://purl.uniprot.org/citations/20452482http://purl.uniprot.org/core/author"Vaisbuch E."xsd:string
http://purl.uniprot.org/citations/20452482http://purl.uniprot.org/core/author"Oyarzun E."xsd:string
http://purl.uniprot.org/citations/20452482http://purl.uniprot.org/core/date"2010"xsd:gYear
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