| http://purl.uniprot.org/citations/20531236 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20531236 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20531236 | http://www.w3.org/2000/01/rdf-schema#comment | "X11alpha is a neuronal adaptor protein that interacts with the amyloid precursor protein (APP) through a centrally located phosphotyrosine binding domain to inhibit the production of Abeta peptide that is deposited in Alzheimer's disease brains. X11alpha also contains two C-terminal postsynaptic density-95, large discs, zona occludens 1 (PDZ) domains, and we show here that through its PDZ domains, X11alpha interacts with a novel transcription factor, fibrinogen silencer binding protein. Moreover, we show that an X11alpha/fibrinogen silencer binding protein complex signals to the nucleus to repress glycogen synthase kinase-3beta promoter activity. Glycogen synthase kinase-3beta is a favoured candidate kinase for phosphorylating tau in Alzheimer's disease. Our findings show a new function for X11alpha that may impact on Alzheimer's disease pathogenesis."xsd:string |
| http://purl.uniprot.org/citations/20531236 | http://purl.org/dc/terms/identifier | "doi:10.1097/wnr.0b013e32833bfca0"xsd:string |
| http://purl.uniprot.org/citations/20531236 | http://purl.org/dc/terms/identifier | "doi:10.1097/wnr.0b013e32833bfca0"xsd:string |
| http://purl.uniprot.org/citations/20531236 | http://purl.uniprot.org/core/author | "McLoughlin D.M."xsd:string |
| http://purl.uniprot.org/citations/20531236 | http://purl.uniprot.org/core/author | "McLoughlin D.M."xsd:string |
| http://purl.uniprot.org/citations/20531236 | http://purl.uniprot.org/core/author | "Lau K.F."xsd:string |
| http://purl.uniprot.org/citations/20531236 | http://purl.uniprot.org/core/author | "Lau K.F."xsd:string |
| http://purl.uniprot.org/citations/20531236 | http://purl.uniprot.org/core/author | "Miller C.C."xsd:string |
| http://purl.uniprot.org/citations/20531236 | http://purl.uniprot.org/core/author | "Miller C.C."xsd:string |
| http://purl.uniprot.org/citations/20531236 | http://purl.uniprot.org/core/author | "Perkinton M.S."xsd:string |
| http://purl.uniprot.org/citations/20531236 | http://purl.uniprot.org/core/author | "Perkinton M.S."xsd:string |
| http://purl.uniprot.org/citations/20531236 | http://purl.uniprot.org/core/author | "Rodriguez L."xsd:string |
| http://purl.uniprot.org/citations/20531236 | http://purl.uniprot.org/core/author | "Rodriguez L."xsd:string |
| http://purl.uniprot.org/citations/20531236 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20531236 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20531236 | http://purl.uniprot.org/core/name | "NeuroReport"xsd:string |
| http://purl.uniprot.org/citations/20531236 | http://purl.uniprot.org/core/name | "NeuroReport"xsd:string |
| http://purl.uniprot.org/citations/20531236 | http://purl.uniprot.org/core/pages | "761-766"xsd:string |
| http://purl.uniprot.org/citations/20531236 | http://purl.uniprot.org/core/pages | "761-766"xsd:string |
| http://purl.uniprot.org/citations/20531236 | http://purl.uniprot.org/core/title | "An X11alpha/FSBP complex represses transcription of the GSK3beta gene promoter."xsd:string |
| http://purl.uniprot.org/citations/20531236 | http://purl.uniprot.org/core/title | "An X11alpha/FSBP complex represses transcription of the GSK3beta gene promoter."xsd:string |
| http://purl.uniprot.org/citations/20531236 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/20531236 | http://purl.uniprot.org/core/volume | "21"xsd:string |