| http://purl.uniprot.org/citations/20570856 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20570856 | http://www.w3.org/2000/01/rdf-schema#comment | "Tumor-induced immune defects can weaken host immune response and permit tumor cell growth. In a systemic model of murine acute myeloid leukemia (AML), tumor progression resulted in increased regulatory T cells (Treg) and elevation of program death-1 (PD-1) expression on CD8(+) cytotoxic T cells (CTLs) at the tumor site. PD-1 knockout mice were more resistant to AML despite the presence of similar percentage of Tregs compared with wild type. In vitro, intact Treg suppression of CD8(+) T-cell responses was dependent on PD-1 expression by T cells and Tregs and PD-L1 expression by antigen-presenting cells. In vivo, the function of adoptively transferred AML-reactive CTLs was reduced by AML-associated Tregs. Anti-PD-L1 monoclonal antibody treatment increased the proliferation and function of CTLs at tumor sites, reduced AML tumor burden, and resulted in long-term survivors. Treg depletion followed by PD-1/PD-L1 blockade showed superior efficacy for eradication of established AML. These data demonstrated that interaction between PD-1 and PD-L1 can facilitate Treg-induced suppression of T-effector cells and dampen the antitumor immune response. PD-1/PD-L1 blockade coupled with Treg depletion represents an important new approach that can be readily translated into the clinic to improve the therapeutic efficacy of adoptive AML-reactive CTLs in advanced AML disease."xsd:string |
| http://purl.uniprot.org/citations/20570856 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2010-03-275446"xsd:string |
| http://purl.uniprot.org/citations/20570856 | http://purl.uniprot.org/core/author | "Zhou Q."xsd:string |
| http://purl.uniprot.org/citations/20570856 | http://purl.uniprot.org/core/author | "Azuma M."xsd:string |
| http://purl.uniprot.org/citations/20570856 | http://purl.uniprot.org/core/author | "Murphy W.J."xsd:string |
| http://purl.uniprot.org/citations/20570856 | http://purl.uniprot.org/core/author | "Weigel B.J."xsd:string |
| http://purl.uniprot.org/citations/20570856 | http://purl.uniprot.org/core/author | "Riddle M."xsd:string |
| http://purl.uniprot.org/citations/20570856 | http://purl.uniprot.org/core/author | "June C.H."xsd:string |
| http://purl.uniprot.org/citations/20570856 | http://purl.uniprot.org/core/author | "Sharpe A.H."xsd:string |
| http://purl.uniprot.org/citations/20570856 | http://purl.uniprot.org/core/author | "Tolar J."xsd:string |
| http://purl.uniprot.org/citations/20570856 | http://purl.uniprot.org/core/author | "Blazar B.R."xsd:string |
| http://purl.uniprot.org/citations/20570856 | http://purl.uniprot.org/core/author | "Munn D.H."xsd:string |
| http://purl.uniprot.org/citations/20570856 | http://purl.uniprot.org/core/author | "Levine B.L."xsd:string |
| http://purl.uniprot.org/citations/20570856 | http://purl.uniprot.org/core/author | "Vallera D.A."xsd:string |
| http://purl.uniprot.org/citations/20570856 | http://purl.uniprot.org/core/author | "Highfill S.L."xsd:string |
| http://purl.uniprot.org/citations/20570856 | http://purl.uniprot.org/core/author | "Munger M.E."xsd:string |
| http://purl.uniprot.org/citations/20570856 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20570856 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/20570856 | http://purl.uniprot.org/core/pages | "2484-2493"xsd:string |
| http://purl.uniprot.org/citations/20570856 | http://purl.uniprot.org/core/title | "Program death-1 signaling and regulatory T cells collaborate to resist the function of adoptively transferred cytotoxic T lymphocytes in advanced acute myeloid leukemia."xsd:string |
| http://purl.uniprot.org/citations/20570856 | http://purl.uniprot.org/core/volume | "116"xsd:string |
| http://purl.uniprot.org/citations/20570856 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20570856 |
| http://purl.uniprot.org/citations/20570856 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20570856 |
| http://purl.uniprot.org/uniprot/#_Q02242-mappedCitation-20570856 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20570856 |