| http://purl.uniprot.org/citations/20606168 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20606168 | http://www.w3.org/2000/01/rdf-schema#comment | "In up to one-third of patients with acute myeloid leukemia, a C-terminal frame-shift mutation results in abnormal and abundant cytoplasmic accumulation of the usually nucleoli-bound protein nucleophosmin (NPM), and this is thought to function in cancer pathogenesis. Here, we demonstrate a gain-of-function role for cytoplasmic NPM in the inhibition of caspase signaling. The NPM mutant specifically inhibits the activities of the cell-death proteases, caspase-6 and -8, through direct interaction with their cleaved, active forms, but not the immature procaspases. The cytoplasmic NPM mutant not only affords protection from death ligand-induced cell death but also suppresses caspase-6/-8-mediated myeloid differentiation. Our data hence provide a potential explanation for the myeloid-specific involvement of cytoplasmic NPM in the leukemogenesis of a large subset of acute myeloid leukemia."xsd:string |
| http://purl.uniprot.org/citations/20606168 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2009-12-256149"xsd:string |
| http://purl.uniprot.org/citations/20606168 | http://purl.uniprot.org/core/author | "Yan T."xsd:string |
| http://purl.uniprot.org/citations/20606168 | http://purl.uniprot.org/core/author | "Mok Y.K."xsd:string |
| http://purl.uniprot.org/citations/20606168 | http://purl.uniprot.org/core/author | "Lim T.M."xsd:string |
| http://purl.uniprot.org/citations/20606168 | http://purl.uniprot.org/core/author | "Yeoh A.E."xsd:string |
| http://purl.uniprot.org/citations/20606168 | http://purl.uniprot.org/core/author | "Koay E.S."xsd:string |
| http://purl.uniprot.org/citations/20606168 | http://purl.uniprot.org/core/author | "Ang S.T."xsd:string |
| http://purl.uniprot.org/citations/20606168 | http://purl.uniprot.org/core/author | "Leong S.M."xsd:string |
| http://purl.uniprot.org/citations/20606168 | http://purl.uniprot.org/core/author | "Tay K.G."xsd:string |
| http://purl.uniprot.org/citations/20606168 | http://purl.uniprot.org/core/author | "Bte Ahmad B."xsd:string |
| http://purl.uniprot.org/citations/20606168 | http://purl.uniprot.org/core/author | "Chee L.Y."xsd:string |
| http://purl.uniprot.org/citations/20606168 | http://purl.uniprot.org/core/author | "Koh L.P."xsd:string |
| http://purl.uniprot.org/citations/20606168 | http://purl.uniprot.org/core/author | "Tan B.X."xsd:string |
| http://purl.uniprot.org/citations/20606168 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20606168 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/20606168 | http://purl.uniprot.org/core/pages | "3286-3296"xsd:string |
| http://purl.uniprot.org/citations/20606168 | http://purl.uniprot.org/core/title | "Mutant nucleophosmin deregulates cell death and myeloid differentiation through excessive caspase-6 and -8 inhibition."xsd:string |
| http://purl.uniprot.org/citations/20606168 | http://purl.uniprot.org/core/volume | "116"xsd:string |
| http://purl.uniprot.org/citations/20606168 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20606168 |
| http://purl.uniprot.org/citations/20606168 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20606168 |
| http://purl.uniprot.org/uniprot/#_A0A140VJQ2-mappedCitation-20606168 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20606168 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z491-mappedCitation-20606168 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20606168 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z4G7-mappedCitation-20606168 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20606168 |