| http://purl.uniprot.org/citations/20650893 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20650893 | http://www.w3.org/2000/01/rdf-schema#comment | "β-Arrestins, originally discovered to desensitize activated G protein-coupled receptors, (aka seven-transmembrane receptors, 7TMRs) also mediate 7TMR internalization and G protein-independent signaling via these receptors. More recently, several regulatory roles of β-arrestins for atypical 7TMRs and non-7TM receptors have emerged. Here, we uncover an entirely novel regulatory role of β-arrestins in cross-talk between the angiotensin receptor (AT1aR) and a member of the transient receptor potential (TRP) ion channel family, TRPV4. AT1aR and TRPV4 form a constitutive complex in the plasma membrane, and angiotensin stimulation leads to recruitment of β-arrestin 1 to this complex. Surprisingly, angiotensin stimulation results in ubiquitination of TRPV4, a process that requires β-arrestin 1, and subsequently to internalization and functional down-regulation of TRPV4. β-Arrestin 1 interacts with, and acts as an adaptor for AIP4, an E3 ubiquitin ligase responsible for TRPV4 ubiquitination. Thus, our data provide the first evidence of a functional link between β-arrestins and TRPV4 and uncovers an entirely novel mechanism to maintain appropriate intracellular Ca(2+) concentration to avoid excessive Ca(2+) signaling."xsd:string |
| http://purl.uniprot.org/citations/20650893 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m110.141549"xsd:string |
| http://purl.uniprot.org/citations/20650893 | http://purl.uniprot.org/core/author | "Kim J."xsd:string |
| http://purl.uniprot.org/citations/20650893 | http://purl.uniprot.org/core/author | "Lefkowitz R.J."xsd:string |
| http://purl.uniprot.org/citations/20650893 | http://purl.uniprot.org/core/author | "Shukla A.K."xsd:string |
| http://purl.uniprot.org/citations/20650893 | http://purl.uniprot.org/core/author | "Ahn S."xsd:string |
| http://purl.uniprot.org/citations/20650893 | http://purl.uniprot.org/core/author | "Shenoy S.K."xsd:string |
| http://purl.uniprot.org/citations/20650893 | http://purl.uniprot.org/core/author | "Xiao K."xsd:string |
| http://purl.uniprot.org/citations/20650893 | http://purl.uniprot.org/core/author | "Liedtke W."xsd:string |
| http://purl.uniprot.org/citations/20650893 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20650893 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/20650893 | http://purl.uniprot.org/core/pages | "30115-30125"xsd:string |
| http://purl.uniprot.org/citations/20650893 | http://purl.uniprot.org/core/title | "Arresting a transient receptor potential (TRP) channel: beta-arrestin 1 mediates ubiquitination and functional down-regulation of TRPV4."xsd:string |
| http://purl.uniprot.org/citations/20650893 | http://purl.uniprot.org/core/volume | "285"xsd:string |
| http://purl.uniprot.org/citations/20650893 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20650893 |
| http://purl.uniprot.org/citations/20650893 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20650893 |
| http://purl.uniprot.org/uniprot/P29067#attribution-5CCEC1840823C38B06532386D144E4D7 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20650893 |
| http://purl.uniprot.org/uniprot/P29066#attribution-5CCEC1840823C38B06532386D144E4D7 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20650893 |
| http://purl.uniprot.org/uniprot/P29066#attribution-FBD2CEC87D74D758C5D40823C4A52FFE | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20650893 |
| http://purl.uniprot.org/uniprot/Q9ERZ8#attribution-AFF8EB84DCCD3753360381AFD0C7F2DA | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20650893 |
| http://purl.uniprot.org/uniprot/#_A0A8I5ZV19-mappedCitation-20650893 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20650893 |
| http://purl.uniprot.org/uniprot/#_A8K103-mappedCitation-20650893 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20650893 |
| http://purl.uniprot.org/uniprot/#_A0A8A1UAL1-mappedCitation-20650893 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20650893 |
| http://purl.uniprot.org/uniprot/#_A0A8I6ANU0-mappedCitation-20650893 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20650893 |