| http://purl.uniprot.org/citations/20661302 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20661302 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundNMDA-type glutamate receptors (NMDARs) are major contributors to long-term potentiation (LTP), a form of synaptic plasticity implicated in the process of learning and memory. These receptors consist of calcium-permeating NR1 and multiple regulatory NR2 subunits. A majority of studies show that both NR2A and NR2B-containing NMDARs can contribute to LTP, but their unique contributions to this form of synaptic plasticity remain poorly understood.Methodology/principal findingsIn this study, we show that NR2A and NR2B-containing receptors promote LTP differently in the CA1 hippocampus of 1-month old mice, with the NR2A receptors functioning through Ras-GRF2 and its downstream effector, Erk Map kinase, and NR2B receptors functioning independently of these signaling molecules.Conclusions/significanceThis study demonstrates that NR2A-, but not NR2B, containing NMDA receptors induce LTP in pyramidal neurons of the CA1 hippocampus from 1 month old mice through Ras-GRF2 and Erk. This difference add new significance to the observation that the relative levels of these NMDAR subtypes is regulated in neurons, such that NR2A-containing receptors become more prominent late in postnatal development, after sensory experience and synaptic activity."xsd:string |
| http://purl.uniprot.org/citations/20661302 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0011732"xsd:string |
| http://purl.uniprot.org/citations/20661302 | http://purl.uniprot.org/core/author | "Feig L.A."xsd:string |
| http://purl.uniprot.org/citations/20661302 | http://purl.uniprot.org/core/author | "Jin S.X."xsd:string |
| http://purl.uniprot.org/citations/20661302 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20661302 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/20661302 | http://purl.uniprot.org/core/pages | "e11732"xsd:string |
| http://purl.uniprot.org/citations/20661302 | http://purl.uniprot.org/core/title | "Long-term potentiation in the CA1 hippocampus induced by NR2A subunit-containing NMDA glutamate receptors is mediated by Ras-GRF2/Erk map kinase signaling."xsd:string |
| http://purl.uniprot.org/citations/20661302 | http://purl.uniprot.org/core/volume | "5"xsd:string |
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| http://purl.uniprot.org/uniprot/P63085#attribution-543D17D7AB982C7ECF8C27A1692CF3C6 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20661302 |
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