| http://purl.uniprot.org/citations/20688955 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20688955 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20688955 | http://www.w3.org/2000/01/rdf-schema#comment | "An estimated 6% to 7% of the earth's population carries a mutation affecting red blood cell function. The β-thalassemias and sickle cell disease are the most common monogenic disorders caused by these mutations. Increased levels of γ-globin ameliorate the severity of these diseases because fetal hemoglobin (HbF; α2γ2) can effectively replace adult hemoglobin (HbA; α2β2) and counteract polymerization of sickle hemoglobin (HbS; α2β(S)2). Therefore, understanding the molecular mechanism of globin switching is of biologic and clinical importance. Here, we show that the recently identified chromatin factor Friend of Prmt1 (FOP) is a critical modulator of γ-globin gene expression. Knockdown of FOP in adult erythroid progenitors strongly induces HbF. Importantly, γ-globin expression can be elevated in cells from β-thalassemic patients by reducing FOP levels. These observations identify FOP as a novel therapeutic target in β-hemoglobinopathies."xsd:string |
| http://purl.uniprot.org/citations/20688955 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2010-03-274399"xsd:string |
| http://purl.uniprot.org/citations/20688955 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2010-03-274399"xsd:string |
| http://purl.uniprot.org/citations/20688955 | http://purl.uniprot.org/core/author | "Gillemans N."xsd:string |
| http://purl.uniprot.org/citations/20688955 | http://purl.uniprot.org/core/author | "Gillemans N."xsd:string |
| http://purl.uniprot.org/citations/20688955 | http://purl.uniprot.org/core/author | "Grosveld F."xsd:string |
| http://purl.uniprot.org/citations/20688955 | http://purl.uniprot.org/core/author | "Grosveld F."xsd:string |
| http://purl.uniprot.org/citations/20688955 | http://purl.uniprot.org/core/author | "Philipsen S."xsd:string |
| http://purl.uniprot.org/citations/20688955 | http://purl.uniprot.org/core/author | "Philipsen S."xsd:string |
| http://purl.uniprot.org/citations/20688955 | http://purl.uniprot.org/core/author | "Pourfarzad F."xsd:string |
| http://purl.uniprot.org/citations/20688955 | http://purl.uniprot.org/core/author | "Pourfarzad F."xsd:string |
| http://purl.uniprot.org/citations/20688955 | http://purl.uniprot.org/core/author | "van Dijk T.B."xsd:string |
| http://purl.uniprot.org/citations/20688955 | http://purl.uniprot.org/core/author | "van Dijk T.B."xsd:string |
| http://purl.uniprot.org/citations/20688955 | http://purl.uniprot.org/core/author | "von Lindern M."xsd:string |
| http://purl.uniprot.org/citations/20688955 | http://purl.uniprot.org/core/author | "von Lindern M."xsd:string |
| http://purl.uniprot.org/citations/20688955 | http://purl.uniprot.org/core/author | "van Lom K."xsd:string |
| http://purl.uniprot.org/citations/20688955 | http://purl.uniprot.org/core/author | "van Lom K."xsd:string |
| http://purl.uniprot.org/citations/20688955 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20688955 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20688955 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/20688955 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/20688955 | http://purl.uniprot.org/core/pages | "4349-4352"xsd:string |
| http://purl.uniprot.org/citations/20688955 | http://purl.uniprot.org/core/pages | "4349-4352"xsd:string |