| http://purl.uniprot.org/citations/20705056 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20705056 | http://www.w3.org/2000/01/rdf-schema#comment | "Defects in chromosome condensation, segregation or cytokinesis during mitosis disrupt genome integrity and cause organismal death or tumorigenesis. The conserved kinase AIR-2/Aurora B is required for normal execution of all these important mitotic events in Caenorhabditis elegans. TLK-1 has been recently shown to be a substrate and activator of AIR-2 in the presence of another AIR-2 activator ICP-1/INCENP, and to cooperate with AIR-2 to ensure proper mitotic chromosome segregation. However, whether TLK-1 may contribute to chromosome condensation or cytokinesis is unclear. A time-lapse microscopy analysis showed that tlk-1 mutants are defective in chromosome condensation and cytokinesis, in addition to chromosome segregation, during mitosis. Our data indicate that TLK-1 contributes to chromosome condensation and segregation, at least in part, in a manner that is distinct from the ICP-1-mediated mechanism and does not involve loading AIR-2 or condensin proteins to mitotic chromosomes. Moreover, TLK-1 functions in cytokinesis by localizing AIR-2 to the midzone microtubules. The localization pattern of TLK-1 is different from those of ICP-1 and AIR-2, revealing differences in dynamic regulation and association of TLK-1 and ICP-1 towards AIR-2 in vivo. Interestingly, human TLK2 could functionally substitute for tlk-1, suggesting that the mitotic roles of TLK members might be evolutionarily conserved."xsd:string |
| http://purl.uniprot.org/citations/20705056 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2010.07.146"xsd:string |
| http://purl.uniprot.org/citations/20705056 | http://purl.uniprot.org/core/author | "Yang H.J."xsd:string |
| http://purl.uniprot.org/citations/20705056 | http://purl.uniprot.org/core/author | "Wu Y.C."xsd:string |
| http://purl.uniprot.org/citations/20705056 | http://purl.uniprot.org/core/author | "Yeh C.H."xsd:string |
| http://purl.uniprot.org/citations/20705056 | http://purl.uniprot.org/core/author | "Lee I.J."xsd:string |
| http://purl.uniprot.org/citations/20705056 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20705056 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/20705056 | http://purl.uniprot.org/core/pages | "187-193"xsd:string |
| http://purl.uniprot.org/citations/20705056 | http://purl.uniprot.org/core/title | "Caenorhabditis elegans TLK-1 controls cytokinesis by localizing AIR-2/Aurora B to midzone microtubules."xsd:string |
| http://purl.uniprot.org/citations/20705056 | http://purl.uniprot.org/core/volume | "400"xsd:string |
| http://purl.uniprot.org/citations/20705056 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20705056 |
| http://purl.uniprot.org/citations/20705056 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20705056 |
| http://purl.uniprot.org/uniprot/Q86UE8#attribution-BD96A7A52A33D56E9F912E583FB5B6BC | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20705056 |
| http://purl.uniprot.org/uniprot/#_P34314-mappedCitation-20705056 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20705056 |
| http://purl.uniprot.org/uniprot/#_G3MTX3-mappedCitation-20705056 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20705056 |
| http://purl.uniprot.org/uniprot/#_O01427-mappedCitation-20705056 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20705056 |
| http://purl.uniprot.org/uniprot/#_Q2XN10-mappedCitation-20705056 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20705056 |
| http://purl.uniprot.org/uniprot/Q2XN10 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20705056 |
| http://purl.uniprot.org/uniprot/P34314 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20705056 |
| http://purl.uniprot.org/uniprot/G3MTX3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20705056 |
| http://purl.uniprot.org/uniprot/O01427 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20705056 |