| http://purl.uniprot.org/citations/20711192 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20711192 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20711192 | http://www.w3.org/2000/01/rdf-schema#comment | "Allergies to nickel (Ni(2+)) are the most frequent cause of contact hypersensitivity (CHS) in industrialized countries. The efficient development of CHS requires both a T lymphocyte-specific signal and a proinflammatory signal. Here we show that Ni(2+) triggered an inflammatory response by directly activating human Toll-like receptor 4 (TLR4). Ni(2+)-induced TLR4 activation was species-specific, as mouse TLR4 could not generate this response. Studies with mutant TLR4 proteins revealed that the non-conserved histidines 456 and 458 of human TLR4 are required for activation by Ni(2+) but not by the natural ligand lipopolysaccharide. Accordingly, transgenic expression of human TLR4 in TLR4-deficient mice allowed efficient sensitization to Ni(2+) and elicitation of CHS. Our data implicate site-specific human TLR4 inhibition as a potential strategy for therapeutic intervention in CHS that would not affect vital immune responses."xsd:string |
| http://purl.uniprot.org/citations/20711192 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni.1919"xsd:string |
| http://purl.uniprot.org/citations/20711192 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni.1919"xsd:string |
| http://purl.uniprot.org/citations/20711192 | http://purl.uniprot.org/core/author | "Nielsen P.J."xsd:string |
| http://purl.uniprot.org/citations/20711192 | http://purl.uniprot.org/core/author | "Nielsen P.J."xsd:string |
| http://purl.uniprot.org/citations/20711192 | http://purl.uniprot.org/core/author | "Schmidt M."xsd:string |
| http://purl.uniprot.org/citations/20711192 | http://purl.uniprot.org/core/author | "Schmidt M."xsd:string |
| http://purl.uniprot.org/citations/20711192 | http://purl.uniprot.org/core/author | "Mueller V."xsd:string |
| http://purl.uniprot.org/citations/20711192 | http://purl.uniprot.org/core/author | "Mueller V."xsd:string |
| http://purl.uniprot.org/citations/20711192 | http://purl.uniprot.org/core/author | "Skerra A."xsd:string |
| http://purl.uniprot.org/citations/20711192 | http://purl.uniprot.org/core/author | "Skerra A."xsd:string |
| http://purl.uniprot.org/citations/20711192 | http://purl.uniprot.org/core/author | "Roth J."xsd:string |
| http://purl.uniprot.org/citations/20711192 | http://purl.uniprot.org/core/author | "Roth J."xsd:string |
| http://purl.uniprot.org/citations/20711192 | http://purl.uniprot.org/core/author | "Vogl T."xsd:string |
| http://purl.uniprot.org/citations/20711192 | http://purl.uniprot.org/core/author | "Vogl T."xsd:string |
| http://purl.uniprot.org/citations/20711192 | http://purl.uniprot.org/core/author | "Martin S.F."xsd:string |
| http://purl.uniprot.org/citations/20711192 | http://purl.uniprot.org/core/author | "Martin S.F."xsd:string |
| http://purl.uniprot.org/citations/20711192 | http://purl.uniprot.org/core/author | "Galanos C."xsd:string |
| http://purl.uniprot.org/citations/20711192 | http://purl.uniprot.org/core/author | "Galanos C."xsd:string |
| http://purl.uniprot.org/citations/20711192 | http://purl.uniprot.org/core/author | "Kalis C."xsd:string |
| http://purl.uniprot.org/citations/20711192 | http://purl.uniprot.org/core/author | "Kalis C."xsd:string |
| http://purl.uniprot.org/citations/20711192 | http://purl.uniprot.org/core/author | "Keck S."xsd:string |
| http://purl.uniprot.org/citations/20711192 | http://purl.uniprot.org/core/author | "Keck S."xsd:string |