| http://purl.uniprot.org/citations/20724660 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20724660 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20724660 | http://www.w3.org/2000/01/rdf-schema#comment | "The rapid induction of type I IFN is a central event of the innate defense against viral infections and is tightly regulated by a number of cellular molecules. Viral components induce strong type I IFN responses through the activation of toll-like receptors (TLRs) and intracellular cytoplasmic receptors such as an RNA helicase RIG-I and/or MDA5. According to recent studies, the NF-kappaB essential modulator (NEMO, also called IKKgamma) is crucial for this virus-induced antiviral response. However, the precise roles of signal activation by NEMO adaptor have not been elucidated. Here, we show that virus-induced IRF3 and NF-kappaB activation depends on the K(lys)-27-linked polyubiquitination to NEMO by the novel ubiquitin E3 ligase triparite motif protein 23 (TRIM23). Virus-induced IRF3 and NF-kappaB activation, as well as K27-linked NEMO polyubiquitination, were abrogated in TRIM23 knockdown cells, whereas TRIM23 knockdown had no effect on TNFalpha-mediated NF-kappaB activation. Furthermore, in NEMO-deficient mouse embryo fibroblast cells, IFN-stimulated response element-driven reporter activity was restored by ectopic expression of WT NEMO, as expected, but only partial recovery by NEMO K165/309/325/326/344R multipoints mutant on which TRIM23-mediated ubiquitin conjugation was substantially reduced. Thus, we conclude that TRIM23-mediated ubiquitin conjugation to NEMO is essential for TLR3- and RIG-I/MDA5-mediated antiviral innate and inflammatory responses."xsd:string |
| http://purl.uniprot.org/citations/20724660 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1004621107"xsd:string |
| http://purl.uniprot.org/citations/20724660 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1004621107"xsd:string |
| http://purl.uniprot.org/citations/20724660 | http://purl.uniprot.org/core/author | "Tanaka K."xsd:string |
| http://purl.uniprot.org/citations/20724660 | http://purl.uniprot.org/core/author | "Tanaka K."xsd:string |
| http://purl.uniprot.org/citations/20724660 | http://purl.uniprot.org/core/author | "Murakami Y."xsd:string |
| http://purl.uniprot.org/citations/20724660 | http://purl.uniprot.org/core/author | "Murakami Y."xsd:string |
| http://purl.uniprot.org/citations/20724660 | http://purl.uniprot.org/core/author | "Shimotohno K."xsd:string |
| http://purl.uniprot.org/citations/20724660 | http://purl.uniprot.org/core/author | "Shimotohno K."xsd:string |
| http://purl.uniprot.org/citations/20724660 | http://purl.uniprot.org/core/author | "Akira S."xsd:string |
| http://purl.uniprot.org/citations/20724660 | http://purl.uniprot.org/core/author | "Akira S."xsd:string |
| http://purl.uniprot.org/citations/20724660 | http://purl.uniprot.org/core/author | "Takeuchi O."xsd:string |
| http://purl.uniprot.org/citations/20724660 | http://purl.uniprot.org/core/author | "Takeuchi O."xsd:string |
| http://purl.uniprot.org/citations/20724660 | http://purl.uniprot.org/core/author | "Okawa K."xsd:string |
| http://purl.uniprot.org/citations/20724660 | http://purl.uniprot.org/core/author | "Okawa K."xsd:string |
| http://purl.uniprot.org/citations/20724660 | http://purl.uniprot.org/core/author | "Funami K."xsd:string |
| http://purl.uniprot.org/citations/20724660 | http://purl.uniprot.org/core/author | "Funami K."xsd:string |
| http://purl.uniprot.org/citations/20724660 | http://purl.uniprot.org/core/author | "Saeki Y."xsd:string |
| http://purl.uniprot.org/citations/20724660 | http://purl.uniprot.org/core/author | "Saeki Y."xsd:string |
| http://purl.uniprot.org/citations/20724660 | http://purl.uniprot.org/core/author | "Arimoto K."xsd:string |
| http://purl.uniprot.org/citations/20724660 | http://purl.uniprot.org/core/author | "Arimoto K."xsd:string |
| http://purl.uniprot.org/citations/20724660 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20724660 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |