| http://purl.uniprot.org/citations/20731382 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20731382 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20731382 | http://www.w3.org/2000/01/rdf-schema#comment | "The botulinum neurotoxins (BoNTs) are the most potent protein toxins for humans. There are seven serotypes of BoNTs (A-G) based on a lack of cross antiserum neutralization. BoNTs utilize gangliosides as components of the host receptors for binding and entry into neurons. Members of BoNT/C and BoNT/D serotypes include mosaic toxins that are organized in D/C and C/D toxins. One D/C mosaic toxin, BoNT/D-South Africa (BoNT/D-SA), was not fully neutralized by immunization with BoNT serotype C or D, which stimulated this study. Here the crystal structures of the receptor binding domains of BoNT/C, BoNT/D, and BoNT/D-SA are presented. Biochemical and cell binding studies show that BoNT/C and BoNT/D-SA possess unique mechanisms for ganglioside binding. These studies provide new information about how the BoNTs can enter host cells as well as a basis for understanding the immunological diversity of these neurotoxins."xsd:string |
| http://purl.uniprot.org/citations/20731382 | http://purl.org/dc/terms/identifier | "doi:10.1021/bi100865f"xsd:string |
| http://purl.uniprot.org/citations/20731382 | http://purl.org/dc/terms/identifier | "doi:10.1021/bi100865f"xsd:string |
| http://purl.uniprot.org/citations/20731382 | http://purl.uniprot.org/core/author | "Baldwin M.R."xsd:string |
| http://purl.uniprot.org/citations/20731382 | http://purl.uniprot.org/core/author | "Baldwin M.R."xsd:string |
| http://purl.uniprot.org/citations/20731382 | http://purl.uniprot.org/core/author | "Barbieri J.T."xsd:string |
| http://purl.uniprot.org/citations/20731382 | http://purl.uniprot.org/core/author | "Barbieri J.T."xsd:string |
| http://purl.uniprot.org/citations/20731382 | http://purl.uniprot.org/core/author | "Fu Z."xsd:string |
| http://purl.uniprot.org/citations/20731382 | http://purl.uniprot.org/core/author | "Fu Z."xsd:string |
| http://purl.uniprot.org/citations/20731382 | http://purl.uniprot.org/core/author | "Kim J.J."xsd:string |
| http://purl.uniprot.org/citations/20731382 | http://purl.uniprot.org/core/author | "Kim J.J."xsd:string |
| http://purl.uniprot.org/citations/20731382 | http://purl.uniprot.org/core/author | "Karalewitz A.P."xsd:string |
| http://purl.uniprot.org/citations/20731382 | http://purl.uniprot.org/core/author | "Karalewitz A.P."xsd:string |
| http://purl.uniprot.org/citations/20731382 | http://purl.uniprot.org/core/author | "Kroken A.R."xsd:string |
| http://purl.uniprot.org/citations/20731382 | http://purl.uniprot.org/core/author | "Kroken A.R."xsd:string |
| http://purl.uniprot.org/citations/20731382 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20731382 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20731382 | http://purl.uniprot.org/core/name | "Biochemistry"xsd:string |
| http://purl.uniprot.org/citations/20731382 | http://purl.uniprot.org/core/name | "Biochemistry"xsd:string |
| http://purl.uniprot.org/citations/20731382 | http://purl.uniprot.org/core/pages | "8117-8126"xsd:string |
| http://purl.uniprot.org/citations/20731382 | http://purl.uniprot.org/core/pages | "8117-8126"xsd:string |
| http://purl.uniprot.org/citations/20731382 | http://purl.uniprot.org/core/title | "Identification of a unique ganglioside binding loop within botulinum neurotoxins C and D-SA."xsd:string |
| http://purl.uniprot.org/citations/20731382 | http://purl.uniprot.org/core/title | "Identification of a unique ganglioside binding loop within botulinum neurotoxins C and D-SA."xsd:string |