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Chondroitin sulfate N-acetylgalactosaminyltransferase-1 is required for normal cartilage development.

Watanabe Y., Takeuchi K., Higa Onaga S., Sato M., Tsujita M., Abe M., Natsume R., Li M., Furuichi T., Saeki M., Izumikawa T., Hasegawa A., Yokoyama M., Ikegawa S., Sakimura K., Amizuka N., Kitagawa H., Igarashi M.

CS (chondroitin sulfate) is a glycosaminoglycan species that is widely distributed in the extracellular matrix. To understand the physiological roles of enzymes involved in CS synthesis, we produced CSGalNAcT1 (CS N-acetylgalactosaminyltransferase 1)-null mice. CS production was reduced by approximately half in CSGalNAcT1-null mice, and the amount of short-chain CS was also reduced. Moreover, the cartilage of the null mice was significantly smaller than that of wild-type mice. Additionally, type-II collagen fibres in developing cartilage were abnormally aggregated and disarranged in the homozygous mutant mice. These results suggest that CSGalNAcT1 is required for normal CS production in developing cartilage.

Biochem. J. 432:47-55(2010) [PubMed] [Europe PMC]

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