| http://purl.uniprot.org/citations/20969476 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20969476 | http://www.w3.org/2000/01/rdf-schema#comment | "Oxidative stress is commonly implicated in aging and neurodegenerative conditions such as Parkinson's disease (PD). Mutations in DJ-1 are associated with autosomal recessive early-onset PD. We investigated whether DJ-1 can be degraded in oxidative-stressed dopaminergic neuronal cells, leading to loss of its protective role against oxidative stress. We have shown previously and herein that the active form of matrix metalloproteinase-3 (MMP3) was accumulated in dopamine-producing CATH.a cells in the presence of MPP(+). We show that catalytically active MMP3 cleaved DJ-1, and impaired its antioxidant function. In CATH.a cells, both monomeric and dimeric forms of DJ-1 were diminished in the presence of MPP(+), and this was reversed by MMP3 knockdown or inhibition. While DJ-1 expression was decreased in the substantia nigra of mice administered with MPTP, its degradation was largely attenuated in MMP3 knockout mice. The AKT-signaling pathway, thought to mediate the effect of DJ-1 on cell survival, was also altered. MPP(+) caused decrease in both phospho-Thr308 and phospho-Ser473 forms of AKT, and this was restored by NNGH. Our data suggest that DJ-1 is fragmented by the intracellular MMP3 in response to cell stress, abolishing the protective role of DJ-1 against oxidative damage, and this contributes to the pathogenesis of PD."xsd:string |
| http://purl.uniprot.org/citations/20969476 | http://purl.org/dc/terms/identifier | "doi:10.1089/ars.2009.3059"xsd:string |
| http://purl.uniprot.org/citations/20969476 | http://purl.uniprot.org/core/author | "Kim Y.S."xsd:string |
| http://purl.uniprot.org/citations/20969476 | http://purl.uniprot.org/core/author | "Lee J."xsd:string |
| http://purl.uniprot.org/citations/20969476 | http://purl.uniprot.org/core/author | "Lee K.H."xsd:string |
| http://purl.uniprot.org/citations/20969476 | http://purl.uniprot.org/core/author | "Hwang O."xsd:string |
| http://purl.uniprot.org/citations/20969476 | http://purl.uniprot.org/core/author | "Beal M.F."xsd:string |
| http://purl.uniprot.org/citations/20969476 | http://purl.uniprot.org/core/author | "Choi D.H."xsd:string |
| http://purl.uniprot.org/citations/20969476 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/20969476 | http://purl.uniprot.org/core/name | "Antioxid Redox Signal"xsd:string |
| http://purl.uniprot.org/citations/20969476 | http://purl.uniprot.org/core/pages | "2137-2150"xsd:string |
| http://purl.uniprot.org/citations/20969476 | http://purl.uniprot.org/core/title | "DJ-1 cleavage by matrix metalloproteinase 3 mediates oxidative stress-induced dopaminergic cell death."xsd:string |
| http://purl.uniprot.org/citations/20969476 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/20969476 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20969476 |
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