| http://purl.uniprot.org/citations/20980617 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20980617 | http://www.w3.org/2000/01/rdf-schema#comment | "Deletion of the paralogs ZDS1 and ZDS2 in the budding yeast Saccharomyces cerevisiae causes a mis-regulation of polarized cell growth. Here we show a function for these genes as regulators of the Swe1p (Wee1p) kinase-dependent G2/M checkpoint. We identified a conserved domain in the C-terminus of Zds2p consisting of amino acids 813-912 (hereafter referred to as ZH4 for Zds homology 4) that is required for regulation of Swe1p-dependent polarized bud growth. ZH4 is shown by protein affinity assays to be necessary and sufficient for interaction with Cdc55p, a regulatory subunit of protein phosphatase 2A (PP2A). We hypothesized that the Zds proteins are in a pathway that negatively regulates the Swe1p-dependent G2/M checkpoint via Cdc55p. Supporting this model, deletion of CDC55 rescues the aberrant bud morphology of a zds1Δzds2Δ strain. We also show that expression of ZDS1 or ZDS2 from a strong galactose-inducible promoter can induce mitosis even when the Swe1p-dependent G2/M checkpoint is activated by mis-organization of the actin cytoskeleton. This negative regulation requires the CDC55 gene. Together these data indicate that the Cdc55p/Zds2p module has a function in the regulation of the Swe1p-dependent G2/M checkpoint."xsd:string |
| http://purl.uniprot.org/citations/20980617 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e10-04-0326"xsd:string |
| http://purl.uniprot.org/citations/20980617 | http://purl.uniprot.org/core/author | "Fields S."xsd:string |
| http://purl.uniprot.org/citations/20980617 | http://purl.uniprot.org/core/author | "Kozminski K.G."xsd:string |
| http://purl.uniprot.org/citations/20980617 | http://purl.uniprot.org/core/author | "Vignali M."xsd:string |
| http://purl.uniprot.org/citations/20980617 | http://purl.uniprot.org/core/author | "Ryder M."xsd:string |
| http://purl.uniprot.org/citations/20980617 | http://purl.uniprot.org/core/author | "Dighe S.A."xsd:string |
| http://purl.uniprot.org/citations/20980617 | http://purl.uniprot.org/core/author | "Tameire F."xsd:string |
| http://purl.uniprot.org/citations/20980617 | http://purl.uniprot.org/core/author | "Yasutis K."xsd:string |
| http://purl.uniprot.org/citations/20980617 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20980617 | http://purl.uniprot.org/core/name | "Mol Biol Cell"xsd:string |
| http://purl.uniprot.org/citations/20980617 | http://purl.uniprot.org/core/pages | "4373-4386"xsd:string |
| http://purl.uniprot.org/citations/20980617 | http://purl.uniprot.org/core/title | "Zds2p regulates Swe1p-dependent polarized cell growth in Saccharomyces cerevisiae via a novel Cdc55p interaction domain."xsd:string |
| http://purl.uniprot.org/citations/20980617 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/20980617 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20980617 |
| http://purl.uniprot.org/citations/20980617 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20980617 |
| http://purl.uniprot.org/uniprot/Q00362#attribution-E430C231CDBCD6BD871742BC22F0E4F0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20980617 |
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| http://purl.uniprot.org/uniprot/#_P50111-mappedCitation-20980617 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20980617 |
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