| http://purl.uniprot.org/citations/21048939 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21048939 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundMutations within the leucine-rich repeat kinase 2 (LRRK2) gene are a common cause of familial and sporadic Parkinson's disease. The multidomain protein LRRK2 exhibits overall low GTPase and kinase activity in vitro.Methodology/principal findingsHere, we show that the rho guanine nucleotide exchange factor ARHGEF7 and the small GTPase CDC42 are interacting with LRRK2 in vitro and in vivo. GTPase activity of full-length LRRK2 increases in the presence of recombinant ARHGEF7. Interestingly, LRRK2 phosphorylates ARHGEF7 in vitro at previously unknown phosphorylation sites. We provide evidence that ARHGEF7 might act as a guanine nucleotide exchange factor for LRRK2 and that R1441C mutant LRRK2 with reduced GTP hydrolysis activity also shows reduced binding to ARHGEF7.Conclusions/significanceDownstream effects of phosphorylation of ARHGEF7 through LRRK2 could be (i) a feedback control mechanism for LRRK2 activity as well as (ii) an impact of LRRK2 on actin cytoskeleton regulation. A newly identified familial mutation N1437S, localized within the GTPase domain of LRRK2, further underlines the importance of the GTPase domain of LRRK2 in Parkinson's disease pathogenesis."xsd:string |
| http://purl.uniprot.org/citations/21048939 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0013762"xsd:string |
| http://purl.uniprot.org/citations/21048939 | http://purl.uniprot.org/core/author | "Riess O."xsd:string |
| http://purl.uniprot.org/citations/21048939 | http://purl.uniprot.org/core/author | "Gloeckner C.J."xsd:string |
| http://purl.uniprot.org/citations/21048939 | http://purl.uniprot.org/core/author | "Biskup S."xsd:string |
| http://purl.uniprot.org/citations/21048939 | http://purl.uniprot.org/core/author | "Schulte C."xsd:string |
| http://purl.uniprot.org/citations/21048939 | http://purl.uniprot.org/core/author | "Ueffing M."xsd:string |
| http://purl.uniprot.org/citations/21048939 | http://purl.uniprot.org/core/author | "Bonin M."xsd:string |
| http://purl.uniprot.org/citations/21048939 | http://purl.uniprot.org/core/author | "Gillardon F."xsd:string |
| http://purl.uniprot.org/citations/21048939 | http://purl.uniprot.org/core/author | "Haebig K."xsd:string |
| http://purl.uniprot.org/citations/21048939 | http://purl.uniprot.org/core/author | "Miralles M.G."xsd:string |
| http://purl.uniprot.org/citations/21048939 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/21048939 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/21048939 | http://purl.uniprot.org/core/pages | "e13762"xsd:string |
| http://purl.uniprot.org/citations/21048939 | http://purl.uniprot.org/core/title | "ARHGEF7 (Beta-PIX) acts as guanine nucleotide exchange factor for leucine-rich repeat kinase 2."xsd:string |
| http://purl.uniprot.org/citations/21048939 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/21048939 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21048939 |
| http://purl.uniprot.org/citations/21048939 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21048939 |
| http://purl.uniprot.org/uniprot/Q14155#attribution-88712CF4F063C3271D85F005CB8F04AA | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21048939 |
| http://purl.uniprot.org/uniprot/Q14155#attribution-B7DA6B9D1CF5E66AC7B4B0BEBA3C3E13 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21048939 |
| http://purl.uniprot.org/uniprot/Q9ES28#attribution-B7DA6B9D1CF5E66AC7B4B0BEBA3C3E13 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21048939 |
| http://purl.uniprot.org/uniprot/P60766#attribution-B7DA6B9D1CF5E66AC7B4B0BEBA3C3E13 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21048939 |
| http://purl.uniprot.org/uniprot/P60953#attribution-88712CF4F063C3271D85F005CB8F04AA | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21048939 |
| http://purl.uniprot.org/uniprot/Q5S007#attribution-88712CF4F063C3271D85F005CB8F04AA | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21048939 |