| http://purl.uniprot.org/citations/21063390 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21063390 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21063390 | http://www.w3.org/2000/01/rdf-schema#comment | "Proper attachment of microtubules to kinetochores is essential for accurate chromosome segregation. Here, we report a novel protein involved in kinetochore-microtubule attachment, chromosome alignment-maintaining phosphoprotein (CAMP) (C13orf8, ZNF828). CAMP is a zinc-finger protein containing three characteristic repeat motifs termed the WK, SPE, and FPE motifs. CAMP localizes to chromosomes and the spindle including kinetochores, and undergoes CDK1-dependent phosphorylation at multiple sites during mitosis. CAMP-depleted cells showed severe chromosome misalignment, which was associated with the poor resistance of K-fibres to the tension exerted upon establishment of sister kinetochore bi-orientation. We found that the FPE region, which is responsible for spindle and kinetochore localization, is essential for proper chromosome alignment. The C-terminal region containing the zinc-finger domains negatively regulates chromosome alignment, and phosphorylation in the FPE region counteracts this regulation. Kinetochore localization of CENP-E and CENP-F was affected by CAMP depletion, and by expressing CAMP mutants that cannot functionally rescue CAMP depletion, placing CENP-E and CENP-F as downstream effectors of CAMP. These data suggest that CAMP is required for maintaining kinetochore-microtubule attachment during bi-orientation."xsd:string |
| http://purl.uniprot.org/citations/21063390 | http://purl.org/dc/terms/identifier | "doi:10.1038/emboj.2010.276"xsd:string |
| http://purl.uniprot.org/citations/21063390 | http://purl.org/dc/terms/identifier | "doi:10.1038/emboj.2010.276"xsd:string |
| http://purl.uniprot.org/citations/21063390 | http://purl.uniprot.org/core/author | "Tanaka K."xsd:string |
| http://purl.uniprot.org/citations/21063390 | http://purl.uniprot.org/core/author | "Tanaka K."xsd:string |
| http://purl.uniprot.org/citations/21063390 | http://purl.uniprot.org/core/author | "Chiba S."xsd:string |
| http://purl.uniprot.org/citations/21063390 | http://purl.uniprot.org/core/author | "Chiba S."xsd:string |
| http://purl.uniprot.org/citations/21063390 | http://purl.uniprot.org/core/author | "Mizuno K."xsd:string |
| http://purl.uniprot.org/citations/21063390 | http://purl.uniprot.org/core/author | "Mizuno K."xsd:string |
| http://purl.uniprot.org/citations/21063390 | http://purl.uniprot.org/core/author | "Watanabe K."xsd:string |
| http://purl.uniprot.org/citations/21063390 | http://purl.uniprot.org/core/author | "Watanabe K."xsd:string |
| http://purl.uniprot.org/citations/21063390 | http://purl.uniprot.org/core/author | "Itoh G."xsd:string |
| http://purl.uniprot.org/citations/21063390 | http://purl.uniprot.org/core/author | "Itoh G."xsd:string |
| http://purl.uniprot.org/citations/21063390 | http://purl.uniprot.org/core/author | "Uchida K.S."xsd:string |
| http://purl.uniprot.org/citations/21063390 | http://purl.uniprot.org/core/author | "Uchida K.S."xsd:string |
| http://purl.uniprot.org/citations/21063390 | http://purl.uniprot.org/core/author | "Yasui A."xsd:string |
| http://purl.uniprot.org/citations/21063390 | http://purl.uniprot.org/core/author | "Yasui A."xsd:string |
| http://purl.uniprot.org/citations/21063390 | http://purl.uniprot.org/core/author | "Hirota T."xsd:string |
| http://purl.uniprot.org/citations/21063390 | http://purl.uniprot.org/core/author | "Hirota T."xsd:string |
| http://purl.uniprot.org/citations/21063390 | http://purl.uniprot.org/core/author | "Kanno S."xsd:string |
| http://purl.uniprot.org/citations/21063390 | http://purl.uniprot.org/core/author | "Kanno S."xsd:string |
| http://purl.uniprot.org/citations/21063390 | http://purl.uniprot.org/core/author | "Sugino S."xsd:string |
| http://purl.uniprot.org/citations/21063390 | http://purl.uniprot.org/core/author | "Sugino S."xsd:string |