| http://purl.uniprot.org/citations/21170593 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21170593 | http://www.w3.org/2000/01/rdf-schema#comment | "Our findings indicate that in ovariectomized female rats abdominal aortic constriction led to significant increases in left ventricular mass, myocyte diameter and heart weight/body weight (HW/BW) value, and decreases in interventricular septal thickness at diastole (IVSd), left ventricular percent fractional shortening (FS) and ejection fraction (EF). These pathophysiological alterations were largely reversed by administration with 17β-estradiol for eight weeks. Furthermore, the enhanced expression of extracellular signal-regulated kinases 1/2 and decreased expression of caveolin-3 were found in left ventricle of AAC group. 17β-estradiol (E(2)) administration increased the expression of caveolin-3 and reduced the level of ERK phosphorylation in these pressure-overloaded rats. Moreover, in cultured neonatal rat cardiomyocytes, E(2) inhibited the hypertrophic response to angiotensin II. This effect was reinforced by the addition of extracellular signal-regulated kinases 1/2 inhibitor PD98059, but was impaired when the cells were pretreated with caveolae disruptor, methyl-β-cyclodextrin (M-β-CD). In conclusion, our data indicate that estrogen attenuates the hypertrophic response induced by pressure overload through down-regulation of extracellular signal-regulated kinases 1/2 phosphorylation and up-regulation of caveolin-3 expression."xsd:string |
| http://purl.uniprot.org/citations/21170593 | http://purl.org/dc/terms/identifier | "doi:10.1007/s11033-010-0630-0"xsd:string |
| http://purl.uniprot.org/citations/21170593 | http://purl.uniprot.org/core/author | "Xu J.W."xsd:string |
| http://purl.uniprot.org/citations/21170593 | http://purl.uniprot.org/core/author | "Fu X.D."xsd:string |
| http://purl.uniprot.org/citations/21170593 | http://purl.uniprot.org/core/author | "Tan Z."xsd:string |
| http://purl.uniprot.org/citations/21170593 | http://purl.uniprot.org/core/author | "Wang T.H."xsd:string |
| http://purl.uniprot.org/citations/21170593 | http://purl.uniprot.org/core/author | "Cui Y.H."xsd:string |
| http://purl.uniprot.org/citations/21170593 | http://purl.uniprot.org/core/author | "Xiang Q.L."xsd:string |
| http://purl.uniprot.org/citations/21170593 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21170593 | http://purl.uniprot.org/core/name | "Mol Biol Rep"xsd:string |
| http://purl.uniprot.org/citations/21170593 | http://purl.uniprot.org/core/pages | "4885-4892"xsd:string |
| http://purl.uniprot.org/citations/21170593 | http://purl.uniprot.org/core/title | "17 beta-estradiol attenuates pressure overload-induced myocardial hypertrophy through regulating caveolin-3 protein in ovariectomized female rats."xsd:string |
| http://purl.uniprot.org/citations/21170593 | http://purl.uniprot.org/core/volume | "38"xsd:string |
| http://purl.uniprot.org/citations/21170593 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21170593 |
| http://purl.uniprot.org/citations/21170593 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21170593 |
| http://purl.uniprot.org/uniprot/P51638#attribution-A8E847BF88EACC52DE2B91CBB6EF2D46 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21170593 |
| http://purl.uniprot.org/uniprot/#_P51638-mappedCitation-21170593 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21170593 |
| http://purl.uniprot.org/uniprot/P51638 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21170593 |