| http://purl.uniprot.org/citations/21173252 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21173252 | http://www.w3.org/2000/01/rdf-schema#comment | "Brown adipocytes are multilocular lipid storage cells that play a crucial role in nonshivering thermogenesis. Uncoupling protein 1 (UCP1) is a unique feature of brown fat cells that allows heat generation on sympathetic nervous system stimulation. As conventional transcriptional factors that are activated in various signaling pathways, liver-X receptors (LXRs) play important roles in many physiological processes. The role of LXRs in the regulation of energy homeostasis remains unclear, however. Female WT, LXRαβ(-/-), LXRα(-/-), and LXRβ(-/-) mice were fed with either a normal diet (ND) or a high-carbohydrate diet (HCD) supplemented with or without GW3965-LXR agonist. LXRαβ(-/-) mice exhibited higher energy expenditure (EE) as well as higher UCP1 expression in brown adipose tissue (BAT) compared with WT mice on the HCD. In addition, long-term treatment of WT mice with GW3965 showed lower EE at thermoneutrality (30 °C) and lower Ucp1 expression level in BAT. Furthermore, H&E staining of the BAT of LXRαβ(-/-) mice exhibited decreased lipid droplet size compared with WT mice on the HCD associated with a more intense UCP1-positive reaction. Quantification of triglyceride (TG) content in BAT showed lower TG accumulation in LXRβ(-/-) mice compared with WT mice. Surprisingly, GW3965 treatment increased TG content (twofold) in the BAT of WT and LXRα(-/-) mice but not in LXRβ(-/-) mice. Furthermore, glucose transporter (GLUT4) in the BAT of LXRα(-/-) and LXRβ(-/-) mice was sixfold and fourfold increased, respectively, compared with WT mice on the ND. These findings suggest that LXRα as well as LXRβ could play a crucial role in the regulation of energy homeostasis in female mice and may be a potential target for the treatment of obesity and energy regulation."xsd:string |
| http://purl.uniprot.org/citations/21173252 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1017884108"xsd:string |
| http://purl.uniprot.org/citations/21173252 | http://purl.uniprot.org/core/author | "Gustafsson J.A."xsd:string |
| http://purl.uniprot.org/citations/21173252 | http://purl.uniprot.org/core/author | "Korach-Andre M."xsd:string |
| http://purl.uniprot.org/citations/21173252 | http://purl.uniprot.org/core/author | "Parini P."xsd:string |
| http://purl.uniprot.org/citations/21173252 | http://purl.uniprot.org/core/author | "Archer A."xsd:string |
| http://purl.uniprot.org/citations/21173252 | http://purl.uniprot.org/core/author | "Barros R.P."xsd:string |
| http://purl.uniprot.org/citations/21173252 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21173252 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/21173252 | http://purl.uniprot.org/core/pages | "403-408"xsd:string |
| http://purl.uniprot.org/citations/21173252 | http://purl.uniprot.org/core/title | "Both liver-X receptor (LXR) isoforms control energy expenditure by regulating brown adipose tissue activity."xsd:string |
| http://purl.uniprot.org/citations/21173252 | http://purl.uniprot.org/core/volume | "108"xsd:string |
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