| http://purl.uniprot.org/citations/21183689 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21183689 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21183689 | http://www.w3.org/2000/01/rdf-schema#comment | "The reticulon (Rtn) family of proteins are localized primarily to the endoplasmic reticulum (ER) of most cells. The Rtn-4 family, (aka Nogo) consists of 3 splice variants of a common gene called Rtn-4A, Rtn-4B, and Rtn-4C. Recently, we identified the Rtn-4B (Nogo-B) protein in endothelial and smooth muscle cells of the vessel wall, and showed that Nogo-B is a regulator of cell migration in vitro and vascular remodeling and angiogenesis in vivo. However, the role of Nogo-B in inflammation is still largely unknown. In the present study, we use 2 models of inflammation to show that endothelial Nogo-B regulates leukocyte transmigration and intercellular adhesion molecule-1 (ICAM-1)-dependent signaling. Mice lacking Nogo-A/B have a marked reduction in neutrophil and monocyte recruitment to sites of inflammation, while Nogo-A/B(-/-) mice engrafted with wild-type (WT) bone marrow still exhibit impaired inflammation compared with WT mice engrafted with Nogo-A/B(-/-) bone marrow, arguing for a critical role of host Nogo in this response. Using human leukocytes and endothelial cells, we show mechanistically that the silencing of Nogo-B with small interfering RNA (siRNA) impairs the transmigration of neutrophils and reduces ICAM-1-stimulated phosphorylation of vascular endothelial-cell cadherin (VE-cadherin). Our results reveal a novel role of endothelial Nogo-B in basic immune functions and provide a key link in the molecular network governing endothelial-cell regulation of diapedesis."xsd:string |
| http://purl.uniprot.org/citations/21183689 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2010-04-281956"xsd:string |
| http://purl.uniprot.org/citations/21183689 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2010-04-281956"xsd:string |
| http://purl.uniprot.org/citations/21183689 | http://purl.uniprot.org/core/author | "Sessa W.C."xsd:string |
| http://purl.uniprot.org/citations/21183689 | http://purl.uniprot.org/core/author | "Sessa W.C."xsd:string |
| http://purl.uniprot.org/citations/21183689 | http://purl.uniprot.org/core/author | "Di Lorenzo A."xsd:string |
| http://purl.uniprot.org/citations/21183689 | http://purl.uniprot.org/core/author | "Di Lorenzo A."xsd:string |
| http://purl.uniprot.org/citations/21183689 | http://purl.uniprot.org/core/author | "Davalos A."xsd:string |
| http://purl.uniprot.org/citations/21183689 | http://purl.uniprot.org/core/author | "Davalos A."xsd:string |
| http://purl.uniprot.org/citations/21183689 | http://purl.uniprot.org/core/author | "Wright P.L."xsd:string |
| http://purl.uniprot.org/citations/21183689 | http://purl.uniprot.org/core/author | "Wright P.L."xsd:string |
| http://purl.uniprot.org/citations/21183689 | http://purl.uniprot.org/core/author | "Manes T.D."xsd:string |
| http://purl.uniprot.org/citations/21183689 | http://purl.uniprot.org/core/author | "Manes T.D."xsd:string |
| http://purl.uniprot.org/citations/21183689 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21183689 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21183689 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/21183689 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/21183689 | http://purl.uniprot.org/core/pages | "2284-2295"xsd:string |
| http://purl.uniprot.org/citations/21183689 | http://purl.uniprot.org/core/pages | "2284-2295"xsd:string |
| http://purl.uniprot.org/citations/21183689 | http://purl.uniprot.org/core/title | "Endothelial reticulon-4B (Nogo-B) regulates ICAM-1-mediated leukocyte transmigration and acute inflammation."xsd:string |
| http://purl.uniprot.org/citations/21183689 | http://purl.uniprot.org/core/title | "Endothelial reticulon-4B (Nogo-B) regulates ICAM-1-mediated leukocyte transmigration and acute inflammation."xsd:string |
| http://purl.uniprot.org/citations/21183689 | http://purl.uniprot.org/core/volume | "117"xsd:string |
| http://purl.uniprot.org/citations/21183689 | http://purl.uniprot.org/core/volume | "117"xsd:string |