| http://purl.uniprot.org/citations/21190959 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21190959 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21190959 | http://www.w3.org/2000/01/rdf-schema#comment | "Epidermal growth factor through the stimulation of epidermal growth factor receptor (EGFR) plays a critical role in the activation of MAPKs and phosphatidylinositol-3-protein kinase/AKT cell survival pathways attributed in many pathological conditions. At the cellular level, such functions involve EGFR overactivation and phosphorylation. In the present study, we describe that human embryonic kidney-293 cells transfected with somatostatin (SST) receptor 5 (SSTR5) exhibit inhibition of EGFR phosphorylation and modulate MAPK and phosphatidylinositol-3-protein kinase/AKT cell survival signaling. Furthermore, suppression of EGFR by using small interference RNA and an antagonist (AG1478) potentiates the SST effect via activation of SSTR5 on signaling molecules. In wild-type human embryonic kidney-293 cells, EGFR/ErbB2 exists as constitutive heterodimers. The presence of SSTR5 leads to the dissociation of the heteromeric complex of EGFR/ErbB2 and display preferential heterodimerization between SSTR5 and EGFR in an agonist-dependent manner. These findings highlight a new undiscovered mechanism and potential role of SSTR5 to attenuate the EGFR-mediated signaling pathways involved in tumorigenesis. Our data indicate that the activation and/or overexpression of SST receptors along with the inhibition of EGFR will serve as an important therapeutic approach in the treatment of ErbB-positive tumors."xsd:string |
| http://purl.uniprot.org/citations/21190959 | http://purl.org/dc/terms/identifier | "doi:10.1210/en.2010-0940"xsd:string |
| http://purl.uniprot.org/citations/21190959 | http://purl.org/dc/terms/identifier | "doi:10.1210/en.2010-0940"xsd:string |
| http://purl.uniprot.org/citations/21190959 | http://purl.uniprot.org/core/author | "Qiu X."xsd:string |
| http://purl.uniprot.org/citations/21190959 | http://purl.uniprot.org/core/author | "Qiu X."xsd:string |
| http://purl.uniprot.org/citations/21190959 | http://purl.uniprot.org/core/author | "Chaudhari N."xsd:string |
| http://purl.uniprot.org/citations/21190959 | http://purl.uniprot.org/core/author | "Chaudhari N."xsd:string |
| http://purl.uniprot.org/citations/21190959 | http://purl.uniprot.org/core/author | "Kumar U."xsd:string |
| http://purl.uniprot.org/citations/21190959 | http://purl.uniprot.org/core/author | "Kumar U."xsd:string |
| http://purl.uniprot.org/citations/21190959 | http://purl.uniprot.org/core/author | "Somvanshi R.K."xsd:string |
| http://purl.uniprot.org/citations/21190959 | http://purl.uniprot.org/core/author | "Somvanshi R.K."xsd:string |
| http://purl.uniprot.org/citations/21190959 | http://purl.uniprot.org/core/author | "Kharmate G."xsd:string |
| http://purl.uniprot.org/citations/21190959 | http://purl.uniprot.org/core/author | "Kharmate G."xsd:string |
| http://purl.uniprot.org/citations/21190959 | http://purl.uniprot.org/core/author | "Rajput P.S."xsd:string |
| http://purl.uniprot.org/citations/21190959 | http://purl.uniprot.org/core/author | "Rajput P.S."xsd:string |
| http://purl.uniprot.org/citations/21190959 | http://purl.uniprot.org/core/author | "Watt H.L."xsd:string |
| http://purl.uniprot.org/citations/21190959 | http://purl.uniprot.org/core/author | "Watt H.L."xsd:string |
| http://purl.uniprot.org/citations/21190959 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21190959 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21190959 | http://purl.uniprot.org/core/name | "Endocrinology"xsd:string |
| http://purl.uniprot.org/citations/21190959 | http://purl.uniprot.org/core/name | "Endocrinology"xsd:string |
| http://purl.uniprot.org/citations/21190959 | http://purl.uniprot.org/core/pages | "931-945"xsd:string |
| http://purl.uniprot.org/citations/21190959 | http://purl.uniprot.org/core/pages | "931-945"xsd:string |