| http://purl.uniprot.org/citations/21215257 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21215257 | http://www.w3.org/2000/01/rdf-schema#comment | "The aim of this study was to investigate the protective effect of inhibition of aquaporin-1 (AQP1) expression against aristolochic acid I (AA-I)-induced apoptosis. HK-2 cells impaired by AA-I were used in this study as the cell model of aristolochic acid nephropathy. Apoptosis was studied by different methods, including 3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT) assays, flow cytometry, and caspase 3 activity assays. We compared AA-I-mediated apoptosis in HK-2 cells with or without knockdown of AQP1 expression by RNA interference. MTT assays showed that AA-I inhibited the viability of HK-2 cells in a time- and concentration-dependent manner. Apoptosis was evidenced by the results of the Annexin V/propidium iodide assay and the occurrence of a sub-G1 peak in cell-cycle analysis. The activity of caspase 3 was found to have been increased by AA-I in a concentration-dependent manner. However, AQP1 RNA interference provided protection against injury in cells treated with AA-I (40 μM) for 24 h and attenuated the number of apoptotic cells. These results suggested that AQP1 plays an important role in AA-I-induced apoptosis and that inhibition of AQP1 expression may protect HK-2 cells from AA-I-induced apoptotic damage."xsd:string |
| http://purl.uniprot.org/citations/21215257 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2010.12.128"xsd:string |
| http://purl.uniprot.org/citations/21215257 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/21215257 | http://purl.uniprot.org/core/author | "Sun L."xsd:string |
| http://purl.uniprot.org/citations/21215257 | http://purl.uniprot.org/core/author | "Zhang L."xsd:string |
| http://purl.uniprot.org/citations/21215257 | http://purl.uniprot.org/core/author | "Zhang L.'"xsd:string |
| http://purl.uniprot.org/citations/21215257 | http://purl.uniprot.org/core/author | "Mei X."xsd:string |
| http://purl.uniprot.org/citations/21215257 | http://purl.uniprot.org/core/author | "Jiang Z."xsd:string |
| http://purl.uniprot.org/citations/21215257 | http://purl.uniprot.org/core/author | "Yong B."xsd:string |
| http://purl.uniprot.org/citations/21215257 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21215257 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/21215257 | http://purl.uniprot.org/core/pages | "68-73"xsd:string |
| http://purl.uniprot.org/citations/21215257 | http://purl.uniprot.org/core/title | "Inhibition of aquaporin-1 expression by RNAi protects against aristolochic acid I-induced apoptosis in human proximal tubular epithelial (HK-2) cells."xsd:string |
| http://purl.uniprot.org/citations/21215257 | http://purl.uniprot.org/core/volume | "405"xsd:string |
| http://purl.uniprot.org/citations/21215257 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21215257 |
| http://purl.uniprot.org/citations/21215257 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21215257 |
| http://purl.uniprot.org/uniprot/P29972#attribution-EBFAF001F00DE5FCB5B69D76A0871A1F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21215257 |